| Benefits of home-based endurance training in lung transplant recipients. | |
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MedLine Citation:
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PMID: 21333761 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: To investigate the effect of home-based exercise training on exercise tolerance, muscle function and quality of life in Lung Transplant Recipients (LTR). METHODS: Twelve LTR and 7 age-matched healthy subjects underwent exercise training (ET, 12-wk, 3x/wk, 40min). Peak aerobic capacity ((peak)), endurance time (T(end)), minute ventilation (), quadriceps strength, percentage of type I fiber (%Ifb), fiber diameters and chronic respiratory questionnaire were assessed before and after ET. A positive response to ET was defined as an improvement in T(end) at least comparable to the mean change observed in healthy subjects. RESULTS: Training significantly improved T(end) (+12±11min), isowatt during exercise (-5.5±2.6L/min), muscle strength (+4.6±2.6kg) and dyspnea score (+0.6±0.9) in LTR (p<0.05), leading to recovery of T(end) and muscle strength up to healthy subjects' values. In responders (n=6), (peak,) %Ifb and fatigue score were improved after training (p<0.05). Non-responders had lower %Ifb and greater delay between surgery and the beginning of the study than responders (56 [21-106] vs. 8 [2-59] months respectively, p=0.03). CONCLUSIONS: Home-based ET was effective to improve exercise tolerance, muscle strength and quality of life in LTR but more successful in patients with moderate muscle dysfunction and in the first years after transplantation. Multicenter and controlled-studies are needed to confirm the benefits and optimal modalities of home training in LTR. |
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Authors:
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Isabelle Vivodtzev; Christophe Pison; Karen Guerrero; Paulette Mezin; Elisabeth Maclet; Jean-Christian Borel; Phillipe Chaffanjon; Rachid Hacini; Olivier Chavanon; Dominique Blin; Bernard Wuyam |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-16 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: - ISSN: 1878-1519 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Inserm U1042, HP2 Laboratory, Joseph Fourier University, 38043 Grenoble, France; CHU de Grenoble, Pole Physiologie Rééducation, Clinique de Physiologie, Sommeil & Exercice, BP217, 38043, Grenoble, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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