Document Detail

Benefits of high frequency oscillatory ventilation for premature infants.
MedLine Citation:
PMID:  20684177     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: High frequency oscillatoryventilation based on optimal lung volume strategy is one of the accepted modes of ventilatory support for respiratory distress syndrome in very low birth weight infants. In 1999 itwas introduced in our unit as the primary ventilation modality for RDS. OBJECTIVES: To evaluate if the shift to HFOV influenced the outcome of ventilated VLBW infants in the neonatal intensive care unit of Carmel Medical Center. METHODS: Data were obtained from the medical charts of VLBW infants born at Carmel Medical Center, and late mortality data from the Israel Ministry of Internal Affairs records. A retrospective analysis and a comparison with a historical control group ventilated by the conventional method were performed. RESULTS: A total of 232 VLBW infants with RDS were mechanically ventilated during the period 1995 to 2003: 120 were ventilated using HFOV during 1999-2003 and 102 infants using CV during 1995-1999. The mean gestational age of survivors was 27.4 +/- 2 weeks in the HFOV group and 28.4 +/- 2 in the conventional ventilation group (P = 0.03). The sub-sample of infants with birth weight < 1000 g ventilated with HFOV showed higher survival rates than the infants in the conventional ventilation group, 53 vs. 25 (64.6% vs. 44.6%) respectively (P < 0.05). A trend for lower incidence of pulmonary interstitial emphysema was observed in the HFOV group. CONCLUSIONS: The introduction of HFOV based on optimal lung volume strategy proved to be an efficient and safe method of ventilation support for VLBW infants in our unit.
Irena Kessel; Dan Waisman; Ofra Barnet-Grinnes; Tali Zim Ben Ari; Avi Rotschild
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  12     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Department of Neonatology, Carmel Medical Center and Rappaport Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel.
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MeSH Terms
Betamethasone / therapeutic use
Birth Weight
Cause of Death
Gestational Age
Glucocorticoids / therapeutic use
High-Frequency Ventilation / statistics & numerical data*
Hospital Mortality
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight*
Intensive Care, Neonatal
Intermittent Positive-Pressure Ventilation / statistics & numerical data
Israel / epidemiology
Patient Discharge / statistics & numerical data
Pulmonary Emphysema / epidemiology
Respiratory Distress Syndrome, Newborn / mortality,  therapy*
Retrospective Studies
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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