| Benefits of high frequency oscillatory ventilation for premature infants. | |
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MedLine Citation:
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PMID: 20684177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: High frequency oscillatoryventilation based on optimal lung volume strategy is one of the accepted modes of ventilatory support for respiratory distress syndrome in very low birth weight infants. In 1999 itwas introduced in our unit as the primary ventilation modality for RDS. OBJECTIVES: To evaluate if the shift to HFOV influenced the outcome of ventilated VLBW infants in the neonatal intensive care unit of Carmel Medical Center. METHODS: Data were obtained from the medical charts of VLBW infants born at Carmel Medical Center, and late mortality data from the Israel Ministry of Internal Affairs records. A retrospective analysis and a comparison with a historical control group ventilated by the conventional method were performed. RESULTS: A total of 232 VLBW infants with RDS were mechanically ventilated during the period 1995 to 2003: 120 were ventilated using HFOV during 1999-2003 and 102 infants using CV during 1995-1999. The mean gestational age of survivors was 27.4 +/- 2 weeks in the HFOV group and 28.4 +/- 2 in the conventional ventilation group (P = 0.03). The sub-sample of infants with birth weight < 1000 g ventilated with HFOV showed higher survival rates than the infants in the conventional ventilation group, 53 vs. 25 (64.6% vs. 44.6%) respectively (P < 0.05). A trend for lower incidence of pulmonary interstitial emphysema was observed in the HFOV group. CONCLUSIONS: The introduction of HFOV based on optimal lung volume strategy proved to be an efficient and safe method of ventilation support for VLBW infants in our unit. |
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Authors:
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Irena Kessel; Dan Waisman; Ofra Barnet-Grinnes; Tali Zim Ben Ari; Avi Rotschild |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Israel Medical Association journal : IMAJ Volume: 12 ISSN: 1565-1088 ISO Abbreviation: Isr. Med. Assoc. J. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100930740 Medline TA: Isr Med Assoc J Country: Israel |
Other Details:
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Languages: eng Pagination: 144-9 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Carmel Medical Center and Rappaport Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel. irinakessel@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Betamethasone
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therapeutic use Birth Weight Cause of Death Female Gestational Age Glucocorticoids / therapeutic use High-Frequency Ventilation / statistics & numerical data* Hospital Mortality Humans Infant, Newborn Infant, Premature* Infant, Very Low Birth Weight* Intensive Care, Neonatal Intermittent Positive-Pressure Ventilation / statistics & numerical data Israel / epidemiology Male Patient Discharge / statistics & numerical data Pulmonary Emphysema / epidemiology Respiratory Distress Syndrome, Newborn / mortality, therapy* Retrospective Studies Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 378-44-9/Betamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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