Document Detail

Benefits of external beam irradiation for peripheral arterial bypass: preliminary report on a phase I study.
MedLine Citation:
PMID:  12419446     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To perform a Phase I study to determine the safety and feasibility of using external beam radiotherapy to prevent neointimal hyperplasia in patients after surgical bypass of occluded infrainguinal arteries. METHODS AND MATERIALS: All patients undergoing operative infrainguinal bypass for chronic ischemia were eligible for enrollment, although those requiring a prosthetic graft were preferentially considered. Immediately after bypass, the distal anastomosis was marked with clips, and the baseline anatomy of the anastomosis was documented with an intraoperative angiogram. The distal anastomotic site and 2 cm of surrounding tissues were irradiated to a total dose of 30 Gy, delivered in 10 fractions. The first dose was given within 48 h of surgery. RESULTS: Twenty-one patients were enrolled in this study. No anastomotic or wound problems or any other short-term complications of the treatment developed. However, at a mean follow-up of 10 months (range 3-18), 12 (57%) of the 21 grafts had occluded. Angiography was performed in 2 patients after successful thrombolysis and demonstrated normal anastomoses without residual stenosis. Evidence of stenosis at the irradiated anastomosis was seen in only 1 of the 21 patients by ongoing ultrasound surveillance. CONCLUSION: Fractionated external irradiation to a total dose of 30 Gy delivered to the distal surgical anastomosis immediately after operative bypass has no short-term complications and was associated with an apparently low rate of intimal hyperplasia. However, any possible gains made by reducing the neointimal hyperplasia at the site of anastomosis were significantly diminished by the high frequency of thrombotic events.
Arvind B Soni; Karl A Illig; Yaron Sternbach; Paul Anthony; Phillip Jacob; Gopal Reddy; John Storey; Richard Gerety; Jacqueline P Williams; Michael Schell; David Waldman; Philip Rubin; Richard Green; Paul Okunieff
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  54     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-06     Completed Date:  2002-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1174-9     Citation Subset:  IM    
Department of Radiation Oncology, University of Rochester Medical Center, 601 ElmwoodAvenue, Rochester, NY 14642, USA.
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MeSH Terms
Aged, 80 and over
Anastomosis, Surgical
Middle Aged
Muscle, Smooth, Vascular / physiology,  radiation effects*
Peripheral Vascular Diseases / surgery*
Radiation Tolerance
Vascular Surgical Procedures*

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