| Benefits of dietary sodium restriction in the management of chronic kidney disease. | |
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MedLine Citation:
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PMID: 19713840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To evaluate the role of restricting dietary sodium intake in chronic kidney disease (CKD) and its complications. RECENT FINDINGS: A consistent line of evidence shows that high dietary sodium intake is a determinant of therapy resistance to blockade of the renin-angiotensin-aldosterone system (RAAS). Addition of sodium restriction to RAAS blockade or to RAAS blockade combined with a diuretic permits a further reduction in urinary protein excretion of approximately 30%, which could be expected to reduce long-term renal risk by 25%. SUMMARY: High sodium intake increases blood pressure and proteinuria, induces glomerular hyperfiltration and blunts the response to RAAS blockade. Although recommended in international guidelines, sodium restriction is not a spearhead in treating renal patients. Sodium status is only rarely mentioned in recent large intervention studies in CKD. Sodium intake in CKD is similar to that in the general population. Reduction of sodium intake to the target of 50-85 mmol/24 h in patients with CKD reduces blood pressure and proteinuria, the latter by approximately 30%, and should be actively pursued to improve outcome in CKD. |
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Authors:
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Jan A Krikken; Gozewijn D Laverman; Gerjan Navis |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 18 ISSN: 1535-3842 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-12-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 531-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II Type 1 Receptor Blockers
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therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use Blood Pressure Chronic Disease Combined Modality Therapy Diet, Sodium-Restricted* Diuretics / therapeutic use Drug Therapy, Combination Glomerular Filtration Rate Humans Kidney Diseases / diet therapy*, drug therapy, etiology Proteinuria / etiology, prevention & control Renin-Angiotensin System Sodium Chloride, Dietary / adverse effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Diuretics; 0/Sodium Chloride, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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