| Benefits of blackberry nectar (Rubus spp.) relative to hypercholesterolemia and lipid peroxidation. | |
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MedLine Citation:
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PMID: 22072342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: In humans, the normal metabolic activity produces free radicals that constantly, along with other risk factors, including hypercholesterolemia may be responsible for the onset of degenerative diseases. Some bioactive compounds present in blackberry (Rubus spp.) have the ability to act as natural antioxidants can make the food to minimize effects on the body caused by reactive oxygen species. OBJECTIVE: This study verified the benefits of blackberry nectar through the quantification of triglycerides, total and fraction cholesterol HDL (high density lipoprotein) and LDL-cholesterol (low density lipoprotein), blood glucose and lipid peroxidation in hypercholesterolemic hamsters. METHODS: Two groups were treated with hypercholesterolemic diets (0.1% cholesterol), one of them receiving an additional 5 mL of nectar daily, and a third (control group) treated only with a standard diet. In the blood the quantification of lipids, blood glucose and lipid peroxidation was performed. In the brain, liver and small intestine the lipid peroxidation was determined and in other organs, histopathological evaluations were carried out. RESULTS: The blackberry nectar reduced the triglycerides serum levels, total cholesterol and LDL-cholesterol in hypercholesterolemic hamsters, without influencing the HDL and blood glucose concentrations. A decrease in the initiation of lipid peroxidation reactions in the blood, brain and small intestine was also observed. Only the liver showed histopathological changes (steatosis), due to excess cholesterol, with no positive influence from the nectar. |
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Authors:
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P R Ferreira de Araujo; V da Silva Santos; A Rodrigues Machado; C Gevehr Fernandes; J A Silva; R da Silva Rodrigues |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Volume: 26 ISSN: 1699-5198 ISO Abbreviation: Nutr Hosp Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-11-10 Completed Date: 2012-03-12 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 9100365 Medline TA: Nutr Hosp Country: Spain |
Other Details:
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Languages: eng Pagination: 984-90 Citation Subset: IM |
Affiliation:
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Department of Agroindustrial Science and Tecnhology, College of Agronomy Elisen Maciel, Federal University of Pelotas, Brazil. paulaufpel@pop.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Beverages Blood Chemical Analysis Blood Glucose / metabolism Body Weight / drug effects Brain Chemistry / drug effects Cholesterol, HDL / blood Cholesterol, LDL / blood Cricetinae Fatty Liver / pathology Fruit / chemistry* Hypercholesterolemia / diet therapy*, pathology Intestine, Small / chemistry, metabolism Lipid Peroxidation / drug effects* Liver / chemistry, metabolism, pathology Male Mesocricetus Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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