| Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syndrome patients. | |
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MedLine Citation:
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PMID: 21834489 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: The effect of ezetimibe-statin combination on inflammatory markers in acute coronary syndrome is unknown. The aim of our study is to evaluate the effect of this combination on the lipid profile, the CRP hs and the sCD40 ligand levels in acute coronary syndrome (ACS) patients. METHODS: This is a randomized, double-blind study including 93 patients admitted for ACS randomized in 2 groups, ezetimibe 10 mg + atorvastatin 10 mg vs atorvastatin 20 mg + placebo, for 12 weeks follow-up; blood samples were collected for lipid profile, ALT, AST, CRP and sCD40L at baseline, 12 hours, 4 weeks, and 12 weeks. RESULTS: There was no significant difference in total cholesterol levels, HDL, LDL, CRP, but there was a significant decrease in sCD40L levels in the ezetimibe combination group, with less side effects in the combination group, mainly myalgia (p = 0.012). CONCLUSION: Ezetimibe combination with low dose statin in patients in acute coronary syndrome could be a safe, potent therapy to reduce LDL level with antiinflammatory effect. |
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Authors:
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Righab Hamdan; Fouad Hajj; Zeina Kadry; Roland Kassab; Elie Salame; Simon Aboujaoude; Rabih Azar; Georges Badaoui |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Le Journal médical libanais. The Lebanese medical journal Volume: 59 ISSN: 0023-9852 ISO Abbreviation: J Med Liban Publication Date: 2011 Apr-Jun |
Date Detail:
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Created Date: 2011-08-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375352 Medline TA: J Med Liban Country: Lebanon |
Other Details:
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Languages: eng Pagination: 65-9 Citation Subset: IM |
Affiliation:
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Hôtel-Dieu de France University Hospital, Beirut, Lebanon. mdrighabh@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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