| Benefit and risks of long-term amiodarone therapy for sustained ventricular tachycardia/fibrillation: minimum of three-year follow-up in 145 patients. | |
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MedLine Citation:
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PMID: 2296879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our experience with amiodarone therapy in 145 consecutively referred patients with medically refractory sustained ventricular tachycardia and/or fibrillation treated for at least 3 years was reviewed. Ninety-seven had sustained ventricular tachycardia; the remaining 48 patients were survivors of sudden cardiac death. The patients had a mean of 3.7 +/- 1.4 unsuccessful anti-arrhythmic drug trials before initiation of amiodarone. The initial doses of amiodarone averaged 845 +/- 258 mg for the first 2 weeks and 56% of all patients received a type I antiarrhythmic drug in addition to amiodarone during the initial phase of therapy. The average maintenance dose of amiodarone was 410 +/- 187 mg per day. All patients were followed for a minimum of 3 years or until death or withdrawal from therapy. The maximum follow-up was a period of 8 years. Thus, the average duration of amiodarone therapy was 39 +/- 26 months, representing 472 patient years of therapeutic time on amiodarone. The incidence of deaths either caused by a documented ventricular tachyarrhythmia or presumed to result from an arrhythmic cause was 5.5% in the first year and 3.4% in each of the second and third years of follow-up. During the entire period of follow-up, 56 patients died of all causes (38.6% of the study population). Survival over the follow-up period was influenced significantly by left ventricular function, as judged by either New York Heart Association Functional Class or objective assessment of left ventricular ejection fraction, which was available in 102 patients.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M Myers; T Peter; D Weiss; P C Nalos; E S Gang; D S Oseran; W J Mandel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American heart journal Volume: 119 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-14 Completed Date: 1990-02-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8-14 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Amiodarone / adverse effects, therapeutic use* Anti-Arrhythmia Agents / therapeutic use Dose-Response Relationship, Drug Follow-Up Studies Humans Middle Aged Retrospective Studies Severity of Illness Index Survival Analysis Tachycardia / drug therapy*, mortality, physiopathology Time Factors Ventricular Fibrillation / drug therapy*, mortality, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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T32HL07380/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone |
| Comments/Corrections | |
Comment In:
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Am Heart J. 1990 Dec;120(6 Pt 1):1482
[PMID:
2104037
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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