Document Detail

Benefit and risks of long-term amiodarone therapy for sustained ventricular tachycardia/fibrillation: minimum of three-year follow-up in 145 patients.
MedLine Citation:
PMID:  2296879     Owner:  NLM     Status:  MEDLINE    
Our experience with amiodarone therapy in 145 consecutively referred patients with medically refractory sustained ventricular tachycardia and/or fibrillation treated for at least 3 years was reviewed. Ninety-seven had sustained ventricular tachycardia; the remaining 48 patients were survivors of sudden cardiac death. The patients had a mean of 3.7 +/- 1.4 unsuccessful anti-arrhythmic drug trials before initiation of amiodarone. The initial doses of amiodarone averaged 845 +/- 258 mg for the first 2 weeks and 56% of all patients received a type I antiarrhythmic drug in addition to amiodarone during the initial phase of therapy. The average maintenance dose of amiodarone was 410 +/- 187 mg per day. All patients were followed for a minimum of 3 years or until death or withdrawal from therapy. The maximum follow-up was a period of 8 years. Thus, the average duration of amiodarone therapy was 39 +/- 26 months, representing 472 patient years of therapeutic time on amiodarone. The incidence of deaths either caused by a documented ventricular tachyarrhythmia or presumed to result from an arrhythmic cause was 5.5% in the first year and 3.4% in each of the second and third years of follow-up. During the entire period of follow-up, 56 patients died of all causes (38.6% of the study population). Survival over the follow-up period was influenced significantly by left ventricular function, as judged by either New York Heart Association Functional Class or objective assessment of left ventricular ejection fraction, which was available in 102 patients.(ABSTRACT TRUNCATED AT 250 WORDS)
M Myers; T Peter; D Weiss; P C Nalos; E S Gang; D S Oseran; W J Mandel
Related Documents :
16267249 - Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake.
7810939 - Cardiac pacing for prevention of recurrent vasovagal syncope.
6191299 - Amiodarone in the management of patients with ventricular tachycardia and ventricular f...
8509569 - Long-term effectiveness of surgical treatment of ectopic atrial tachycardia.
22913329 - Multivariate analysis of successful intravenous line placement in the prehospital setting.
7446409 - Amiodarone in the treatment of cardiac arrhythmias in children: one hundred thirty-five...
9934749 - Randomized controlled trial of lymphoblastoid interferon alpha for chronic hepatitis c ...
24561149 - Sex-related differences in outcomes following transcatheter or surgical aortic valve re...
17654609 - Bleeding complications in skin cancer surgery are associated with warfarin but not aspi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  119     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-14     Completed Date:  1990-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  AIM; IM    
Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Amiodarone / adverse effects,  therapeutic use*
Anti-Arrhythmia Agents / therapeutic use
Dose-Response Relationship, Drug
Follow-Up Studies
Middle Aged
Retrospective Studies
Severity of Illness Index
Survival Analysis
Tachycardia / drug therapy*,  mortality,  physiopathology
Time Factors
Ventricular Fibrillation / drug therapy*,  mortality,  physiopathology
Grant Support
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone
Comment In:
Am Heart J. 1990 Dec;120(6 Pt 1):1482   [PMID:  2104037 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Use of heart rate spectral analysis to study the effects of calcium channel blockers on sympathetic ...
Next Document:  Left ventricular filling shortly after an uncomplicated myocardial infarction as a predictor of subs...