| Benefit, risks and cost-effectiveness of screening for abdominal aortic aneurysm. | |
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MedLine Citation:
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PMID: 20563953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Abdominal aortic aneurysms (AAA) cause a considerable number of deaths. A ruptured AAA is associated with a mortality rate of 80%. The purpose of this study was to summarize the current evidence from published health economic models for the long-term effectiveness and cost-effectiveness of screening programs for AAA. MATERIALS AND METHODS: Medical, economic and health technology assessment (HTA) databases were systematically searched for cost-effectiveness models up to October 2007. Only models with a lifetime time horizon of evaluating AAA screening in men over 65 years were included in the review. Study data were extracted, standardized and summarized in evidence tables and cost-effectiveness plots. RESULTS: We reviewed 8 cost-effectiveness models published between 1993 and 2007 comparing AAA screening and lack of screening in men over 60. One model yielded a loss of life-years at additional costs. The remaining seven models yielded gains in life expectancy ranging from 0.02 to 0.28LYs. Gains in quality-adjusted life expectancy reported by six of the seven models ranged from 0.015 to 0.059 QALYs. Incremental costs ranged from 96 to 721 Euros. Incremental cost-effectiveness ratios (ICER) ranged from 1443 to 13 299 Euros per LY or QALY gained. CONCLUSION: Based on our analysis, the introduction of a screening program to identify AAA will probably gain additional life years and quality of life at acceptable extra costs. The target population for a screening program should be men 65 years and older. |
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Authors:
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T Schmidt; N M?hlberger; I E Chemelli-Steingruber; A Strasak; B Kofler; A Chemelli; U Siebert |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-06-18 |
Journal Detail:
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Title: R?Fo : Fortschritte auf dem Gebiete der R?ntgenstrahlen und der Nuklearmedizin Volume: 182 ISSN: 1438-9010 ISO Abbreviation: Rofo Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507497 Medline TA: Rofo Country: Germany |
Other Details:
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Languages: eng Pagination: 573-80 Citation Subset: IM |
Copyright Information:
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Copyright (c) Georg Thieme Verlag KG Stuttgart-New York. |
Affiliation:
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Public Health, UMIT. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aortic Aneurysm, Abdominal / diagnosis*, economics*, mortality Aortic Rupture / diagnosis, economics, mortality Cost-Benefit Analysis Diagnostic Imaging / economics* Germany Humans Male Mass Screening / economics* Middle Aged Quality-Adjusted Life Years Risk Factors Sex Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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