Document Detail


Benefit of more but smaller meals at a fixed daily protein intake.
MedLine Citation:
PMID:  9467230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of meal frequency on change of body weight and protein status, measured by level of amino acid oxidation (decarboxylation) in the postabsorptive state, was studied at a fixed daily protein intake. Growing rats (250g) were fed through gastric canula a feeding solution based on Nutrison Standard supplying 1.6g protein and 266kJ ME daily. This amount was given in either 2 large meals at the beginning and the end, or in 6 smaller meals, or by continuous infusion during entire dark period (10 hrs). After 3 weeks of feeding the mean growth rate of the rats fed continuously was nearly 20% higher than rats fed the same amount in 2 meals. The rats fed 6 meals a day had a growth rate rather similar to the rats fed continuously. The percentile recovery of label as 14CO2 in the breath after an intraperitoneal injection of [1-14C]leucine (4 hrs after last meal) was significantly higher (p.05) for the animals fed continuously (27% sd 2.6) compared to the rats fed 2 meals (21.9% sd 4.0). The value for 6 meal group was intermediate (24.5 sd 1.8). The results indicate that the metabolic utilization of a fixed daily amount of protein is clearly influenced by the way of supply. With respect to the change of body weight and protein status, animals have more benefit of the same amount of protein if the supply is more equable. It is suggested that the difference is caused by metabolic restriction for an adequate utilisation of large meals. Therefore large meals are supposed to cause a waste of amino acids in the postprandial phase. As a consequence amino acid amount that will be stored in the body to be available in the postabsorptive phase will be less.
Authors:
J Bujko; V V Schreurs; P E Koopmanschap; E Fürstenberg; J S Keller
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Ernährungswissenschaft     Volume:  36     ISSN:  0044-264X     ISO Abbreviation:  Z Ernahrungswiss     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-13     Completed Date:  1998-03-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0413632     Medline TA:  Z Ernahrungswiss     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  347-9     Citation Subset:  IM    
Affiliation:
Faculty of Human Nutrition, Department of Dietetics and Nutritional Physiology, Warsaw Agricultural University, Poland.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism
Animals
Body Weight
Carbon Dioxide / analysis
Carbon Radioisotopes
Dietary Proteins*
Energy Intake
Feeding Behavior*
Growth / physiology*
Leucine / metabolism
Male
Oxidation-Reduction
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Carbon Radioisotopes; 0/Dietary Proteins; 124-38-9/Carbon Dioxide; 61-90-5/Leucine

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