Document Detail

Benefit of measuring basal serum calcitonin to detect medullary thyroid carcinoma in a Danish population with a high prevalence of thyroid nodules.
MedLine Citation:
PMID:  19691107     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Routine measurement of serum calcitonin to detect medullary thyroid carcinoma (MTC) continues to be fiercely debated, although less attention has been paid to the positive predictive value (PPV) of this method. METHODS: We collected data from 959 patients with nontoxic nodular goiter; thyroidectomy was performed in 307 of these patients. RESULTS: Thirty-nine patients had elevated serum calcitonin; 6 of these patients had MTC detected by the initial diagnostic setup. No additional patient in the cohort was registered in the Danish Thyroid Cancer Database, reflecting that all patients with MTC were classified correctly initially. The sensitivity of serum calcitonin for detection of MTC was 100%, the specificity was 95.3%, the positive predictive value was 15.4%, and the negative predictive value was 100%. CONCLUSION: Serum calcitonin has high sensitivity and specificity for detection of MTC. The low PPV might lead to unnecessary thyroid surgery. Thus, the result of serum calcitonin measurement should always be interpreted in the context of other clinical variables.
Martin Hasselgren; Laszlo Hegedüs; Christian Godballe; Steen Joop Bonnema
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Head & neck     Volume:  32     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  612-8     Citation Subset:  IM    
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
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MeSH Terms
Aged, 80 and over
Biopsy, Fine-Needle
Calcitonin / blood*
Carcinoma, Medullary / diagnosis*
Goiter, Nodular / epidemiology,  surgery
Middle Aged
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
Thyroid Gland / pathology
Thyroid Neoplasms / diagnosis*
Tumor Markers, Biological / blood
Ultrasonography, Interventional
Young Adult
Reg. No./Substance:
0/Tumor Markers, Biological; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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