| Benefit of glyceryl trinitrate on arterial stiffness is directly due to effects on peripheral arteries. | |
| | |
MedLine Citation:
|
PMID: 15761047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine how the vasodilator glyceryl trinitrate (GTN) alters arterial stiffness and improves left ventricular afterload. METHODS: Ascending aortic pressure waves were measured with fluid filled catheters of high fidelity in 50 patients undergoing cardiac surgery, before cardiopulmonary bypass, both before and after intravenous infusion of GTN. In all 50 patients, wave reflection was identifiable as a secondary boost to late systolic pressure, permitting the pressure wave to be separated into a primary component, attributable to left ventricular ejection and properties of the proximal aorta, and a secondary component, attributable to reflection of the primary wave from the peripheral vasculature. RESULTS: GTN infusion caused no change in amplitude of the primary wave (mean (SD) 0.0 (1.4) mm Hg, not significant) but substantial reduction (14.6 (9.6) mm Hg, p < 0.0001) in amplitude of the secondary reflected wave. Fall in mean pressure was attributable to a mix of arteriolar and venous dilatation, with relative contributions unable to be separated. CONCLUSION: Favourable effects of GTN on arterial stiffness can be attributed to effects on peripheral muscular arteries, causing reduction in wave reflection. Results conform with previous invasive studies on vasodilator agents and their known effects on calibre and compliance of muscular arteries. |
| | |
Authors:
|
A L Pauca; N D Kon; M F O'Rourke |
Related Documents
:
|
15942427 - The influence of socio-economic status on casual blood pressures of the adult nigerians. 7959797 - Application of pattern recognition and image classification techniques to determine con... 7735497 - Aortic distensibility in normotensive, untreated and treated hypertensive patients. 17944657 - Calibrated photoplethysmographic estimation of digital pulse volume and arterial compli... 6703167 - Users of coin-operated computerized sphygmomanometry and reasons for utilization: a des... 15957627 - Interactive simulation system for artificial ventilation on the internet: virtual venti... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-03-10 |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 91 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2005 Nov |
Date Detail:
|
Created Date: 2005-10-18 Completed Date: 2005-12-15 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 1428-32 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Aorta / drug effects*, physiology Blood Pressure / drug effects* Cardiovascular Diseases / physiopathology Compliance Female Humans Infusions, Intravenous Male Middle Aged Muscle, Skeletal / blood supply Nitroglycerin / pharmacology* Radial Artery / drug effects*, physiology Vascular Resistance / drug effects Vasodilator Agents / pharmacology* Ventricular Function / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 55-63-0/Nitroglycerin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypoxaemia associated with an enlarged aortic root: a new syndrome?
Next Document: Management and outcomes of lower risk patients presenting with acute coronary syndromes in a multina...