Document Detail

Benefit of glyceryl trinitrate on arterial stiffness is directly due to effects on peripheral arteries.
MedLine Citation:
PMID:  15761047     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine how the vasodilator glyceryl trinitrate (GTN) alters arterial stiffness and improves left ventricular afterload.
METHODS: Ascending aortic pressure waves were measured with fluid filled catheters of high fidelity in 50 patients undergoing cardiac surgery, before cardiopulmonary bypass, both before and after intravenous infusion of GTN. In all 50 patients, wave reflection was identifiable as a secondary boost to late systolic pressure, permitting the pressure wave to be separated into a primary component, attributable to left ventricular ejection and properties of the proximal aorta, and a secondary component, attributable to reflection of the primary wave from the peripheral vasculature.
RESULTS: GTN infusion caused no change in amplitude of the primary wave (mean (SD) 0.0 (1.4) mm Hg, not significant) but substantial reduction (14.6 (9.6) mm Hg, p < 0.0001) in amplitude of the secondary reflected wave. Fall in mean pressure was attributable to a mix of arteriolar and venous dilatation, with relative contributions unable to be separated.
CONCLUSION: Favourable effects of GTN on arterial stiffness can be attributed to effects on peripheral muscular arteries, causing reduction in wave reflection. Results conform with previous invasive studies on vasodilator agents and their known effects on calibre and compliance of muscular arteries.
A L Pauca; N D Kon; M F O'Rourke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-03-10
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  91     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2005-12-15     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1428-32     Citation Subset:  AIM; IM    
Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
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MeSH Terms
Aged, 80 and over
Aorta / drug effects*,  physiology
Blood Pressure / drug effects*
Cardiovascular Diseases / physiopathology
Infusions, Intravenous
Middle Aged
Muscle, Skeletal / blood supply
Nitroglycerin / pharmacology*
Radial Artery / drug effects*,  physiology
Vascular Resistance / drug effects
Vasodilator Agents / pharmacology*
Ventricular Function / physiology
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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