| Benefit assessment of salt reduction in patients with hypertension: systematic overview. | |
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MedLine Citation:
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PMID: 21475042 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: We assessed the benefits and harm of reduced salt intake in patients with essential hypertension focusing on patient-relevant outcomes and blood pressure. METHODS: A systematic search of five electronic databases was performed to identify high-quality secondary literature based on randomized controlled trials (RCTs). An update primary literature search (RCTs) was performed for the time period up to 2010 that was not covered by secondary literature. Major outcomes were death, cardiovascular morbidity/mortality, hospital stays, terminal renal failure, quality of life, and adverse events. Change in blood pressure was defined as surrogate parameter. RESULTS: Four different systematic reviews and two RCTs met the inclusion criteria. Only one review reported limited data on patient-relevant outcomes. Over an intervention period of up to 12 months, mean SBP was reduced by 3.6-8.0 mmHg in all reviews. For the same intervention period, a statistically significant advantage with regard to mean DBP reduction ranging from 1.9 to 2.8 mmHg was found in three reviews. The fourth publication reported a nonsignificant reduction (DBP reduction of 4.7 mmHg). None of the RCTs identified in the primary literature search update reported data on patient-relevant outcomes. However, both RCTs found blood pressure improvements with salt reduction. CONCLUSION: A benefit from a salt-reduced diet in patients with high blood pressure is not proven with regard to patient-relevant outcomes based on systematic reviews and RCTs published up to 2010. The results indicate a blood pressure-lowering effect through reduced salt intake in hypertensive patients. |
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Authors:
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Eva Matyas; Klaus Jeitler; Karl Horvath; Thomas Semlitsch; Lars G Hemkens; Nicole Pignitter; Andrea Siebenhofer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 29 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 821-8 Citation Subset: IM |
Affiliation:
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aDepartment of Internal Medicine, EBM Review Center Medical University of Graz, Austria bInstitute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria cInstitute for Quality and Efficiency in Healthcare (IQWiG), Cologne, Germany dInstitute of General Practice, Goethe University Frankfurt, Frankfurt, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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