| The Benefit of Early PET/CT Surveillance in HPV-Associated Head and Neck Squamous Cell Carcinoma. | |
| | |
MedLine Citation:
|
PMID: 22106234 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the ability of posttreatment positron emission tomography and computed tomography (PET/CT) to predict ultimate disease status in patients with head and neck squamous cell carcinoma and known human papillomavirus (HPV) status. DESIGN: Retrospective. SETTING: Single tertiary academic referral center. PATIENTS: Clinical and radiographic data, including HPV status, were available for 62 patients with head and neck squamous cell carcinoma who underwent treatment from 2005 to 2010. MAIN OUTCOME MEASURES: The first posttreatment PET/CT scan, performed between 4 and 16 weeks (median, 9 weeks) after treatment, was categorized as negative, probably negative, or positive for residual disease. The PET/CT and clinical follow-up results, including disease status, were obtained every 3 months thereafter. RESULTS: Among the 62 patients, 35 results (56%) were negative, 15 (24%) were probably negative, and 12 (19%) were positive. Eight of the 27 HPV-negative patients were PET/CT positive compared with 4 of the 35 HPV-positive patients (Cochran-Armitage trend test, P = .11). The median follow-up for disease-free patients was 21 months from the completion of the treatment. Disease-free survival was associated with PET/CT outcome (log-rank P < .001) and HPV status (log-rank P = .01). Using recurrence at 2 years as a reference standard, the early PET/CT scans had a specificity of 69% (95% confidence interval [CI], 46%-91%) and a negative predictive value of 79% (95% CI, 57%-99%). All PET/CT-negative HPV-positive patients (n = 6) were free of disease at 2 years, although this proportion was not statistically different from the PET/CT-negative HPV-positive patients in this small cohort. CONCLUSIONS: A negative posttreatment PET/CT result may have the potential to identify patients who are at very low risk of recurrence. The HPV status may augment the predictive utility of an initial negative PET/CT result. |
| | |
Authors:
|
Irene Zhang; Barton F Branstetter; Daniel M Beswick; Jessica H Maxwell; William E Gooding; Robert L Ferris |
Related Documents
:
|
17895314 - Accuracy of [18f]fluorodopa positron emission tomography for diagnosing and localizing ... 19999354 - Use of 3'-deoxy-3'-[18f]fluorothymidine pet/ct for evaluating response to cytotoxic che... 16330574 - Performance characteristics obtained for a new 3-dimensional lutetium oxyorthosilicate-... 17048034 - The incremental value of 18f-fdg pet/ct in paediatric malignancies. 18250534 - 18f-fdg uptakes in leptomeningeal metastases from carcinoma of the breast on a positron... 2229574 - Proton chemical shift imaging of bone marrow for monitoring therapy in leukemia. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of otolaryngology--head & neck surgery Volume: 137 ISSN: 1538-361X ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 1106-11 Citation Subset: AIM; IM |
Affiliation:
|
Department of Otolaryngology, Eye and Ear Institute, University of Pittsburgh School of Medicine, 200 Lothrop St, Ste 500, Pittsburgh, PA 15213. ferrrl@upmc.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors associated with mortality in 2-year survivors of head and neck cancer.
Next Document: Patient-perceived and objective functional outcomes following transoral robotic surgery for early or...