| Beneficial response to anakinra and thalidomide in Schnitzler's syndrome. | |
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MedLine Citation:
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PMID: 16096327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Schnitzler's syndrome is an inflammatory disorder characterised by chronic urticarial rash and monoclonal gammopathy, accompanied by periodic fever, arthralgia or arthritis, and bone pain. The cause and treatment are still unknown. OBJECTIVE: To assess treatment with thalidomide and an interleukin 1 receptor antagonist, anakinra, in Schnitzler's syndrome. CASE REPORTS: Three patients with Schnitzler's syndrome are described, one with IgM gammopathy, two with IgG type. In one patient, thalidomide induced complete remission, but was stopped because of polyneuropathy. Anakinra 100 mg daily in all three patients led to disappearance of fever and skin lesions within 24 hours. After a follow up of 6-18 months, all patients are free of symptoms. CONCLUSION: Anakinra proved to be effective in three patients with Schnitzler's syndrome. This treatment is preferable to thalidomide, which induced a complete remission in one of our patients, as it has fewer side effects. |
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Authors:
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H D de Koning; E J Bodar; A Simon; J C H van der Hilst; M G Netea; J W M van der Meer |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-08-11 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 65 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-13 Completed Date: 2006-04-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 542-4 Citation Subset: IM |
Affiliation:
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Radboud University Nijmegen Medical Centre, Department of General Internal Medicine, 6500 HB Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antirheumatic Agents
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therapeutic use* Female Follow-Up Studies Humans Interleukin 1 Receptor Antagonist Protein Male Middle Aged Receptors, Interleukin-1 / antagonists & inhibitors Schnitzler Syndrome / drug therapy*, pathology Sialoglycoproteins / therapeutic use* Thalidomide / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Receptors, Interleukin-1; 0/Sialoglycoproteins; 50-35-1/Thalidomide |
| Comments/Corrections | |
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