| Beneficial outcome after prostaglandin-induced post-partum cardiac arrest using levosimendan and extracorporeal membrane oxygenation. | |
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MedLine Citation:
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PMID: 16987377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Administration of high doses of prostaglandins is a frequently performed and effective method for the treatment of atonic uterine haemorrhage in order to increase uterine muscle tone. Rarely, however, these drugs may cause life-threatening complications including bronchospasm, acute pulmonary oedema and myocardial infarction caused by coronary spasms. METHODS: We discuss the management of a patient suffering post-partum atonic uterine bleeding, catecholamine-resistant cardiac arrest and fulminant pulmonary failure due to deleterious side-effects of treatment with prostaglandins. RESULTS: During therapy resistant cardiopulmonary resuscitation, the addition of levosimendan to standard medications resulted in a prompt stabilization of haemodynamics. Subsequent treatment of pulmonary failure was successfully managed with ECMO. CONCLUSION: Although levosimendan is not approved for pharmacological treatment of cardiopulmonary arrest, the beneficial effects in this patient suggest an important role of calcium sensitization and vasodilation during prostaglandin-induced cardiac arrest. |
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Authors:
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J J Krumnikl; W G Toller; G Prenner; H Metzler |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 50 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-09-21 Completed Date: 2006-10-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 768-70 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria. jakub.krumnikl@meduni-graz.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiotonic Agents / therapeutic use* Catecholamines / therapeutic use Cesarean Section Drug Resistance Extracorporeal Membrane Oxygenation* Female Heart Arrest / chemically induced*, drug therapy* Hemodynamics / drug effects Humans Hydrazones / therapeutic use* Lung Diseases / complications, drug therapy Postpartum Hemorrhage / drug therapy Pregnancy Prostaglandins / adverse effects* Pyridazines / therapeutic use* Treatment Outcome Uterine Diseases / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Catecholamines; 0/Hydrazones; 0/Prostaglandins; 0/Pyridazines; 131741-08-7/simendan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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