Document Detail


Beneficial impact of Xuezhikang on cardiovascular events and mortality in elderly hypertensive patients with previous myocardial infarction from the China Coronary Secondary Prevention Study (CCSPS).
MedLine Citation:
PMID:  19602720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coronary heart disease, hypertension, and dyslipidemia are highly prevalent and commonly coexist in people who are middle-aged and older. Previous data suggested that lowering cholesterol concentrations in individuals at high risk of cardiovascular disease improved clinical outcomes. Xuezhikang, a partial extract of red yeast rice containing statin, has a marked impact on lipids. The purpose of this study, therefore, was to evaluate the impact of Xuezhikang on reducing cardiovascular events and mortality in elderly Chinese hypertensive patients with a history of myocardial infarction (MI) enrolled in the Chinese Coronary Secondary Prevention Study. In this randomized trial, 1530 elderly hypertensive patients (> or = 65-years-old) with previous MI were assigned either to placebo (n = 758) or to Xuezhikang (n = 772) daily for an average of 4.5 years. The primary endpoint was recurrent coronary events; the secondary endpoint was all-cause mortality and other clinical events, including adverse effects. There were 68 cases of coronary events (8.8%) detected in the Xuezhikang group and 108 cases (14.3%) in the placebo group (38.2% risk reduction by Xuezhikang therapy). Death from coronary heart disease (CHD) totaled 49 cases in the Xuezhikang group (6.4%) and 68 cases in the placebo group (9.0%), indicating that Xuezhikang significantly decreased the risk of CHD death by 29.2%. Our study demonstrated that Xuezhikang therapy could effectively and safely reduce cardiovascular events and all-cause death in Chinese elderly hypertensive patients with previous MI. This finding may have an important implication for the treatment of elderly hypertensive patients with CHD.
Authors:
Jian-Jun Li; Zong-Liang Lu; Wen-Rong Kou; Zuo Chen; Yang-Feng Wu; Xue-Hai Yu; Yu-Cheng Zhao;
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  49     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  947-56     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, People's Republic of China. lijnjn@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiovascular Diseases / mortality,  prevention & control*
Coronary Disease / mortality,  prevention & control*
Double-Blind Method
Drugs, Chinese Herbal / adverse effects,  therapeutic use*
Female
Follow-Up Studies
Humans
Hypertension / complications,  mortality
Male
Middle Aged
Myocardial Infarction / complications*,  mortality
Risk Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/xuezhikang
Investigator
Investigator/Affiliation:
Y S Xu / ; D F Gu / ; X Jia / ; Z Chen / ; J L Sun / ; J Chen / ; X H Yu / ; J H Wang / ; N Wang / ; R P Zheng / ; S H Zhang / ; C X Liu / ; L H Sun / ; Y C Zhao / ; Y Lin / ; J B Huang / ; D Y Hu / ; X C Yang / ; Y Z Liu / ; M M Gao / ; P Zhang / ; C X Deng / ; Y Liu / ; Z Q Li / ; Y Q Shi / ; T S Hu / ; Y Z Chen / ; S Tan / ; W R Zhao / ; G L Deng / ; W J Huang / ; J C Zhang / ; H Yu / ; Q S Shi / ; X Z Wang / ; B Jiang / ; X R Pan / ; L Li / ; P L Bu / ; M Q Shu / ; Q L Xu / ; J H Zhang / ; W H Ding / ; L Li / ; J J Yang / ; J L Su / ; W D Zhao / ; X Liu / ; L J Li / ; J F Yang / ; Q S Wang / ; T G Huang / ; L F Li / ; L J Zhou / ; J X Guo / ; W H Li / ; Z P Li / ; X G Zhang / ; X M Peng / ; Y W An / ; J Shu / ; L T Ma / ; H Ge / ; M J Zhang / ; Z R Lv / ; J H Li / ; J W Yang / ; L Zhang / ; Y L Cheng / ; J G Chen / ; C W Zhou / ; H H Zhang / ; Y L Huang / ; X F Qu / ; J J LI / ; H Guo / ; G X Wang / ; S Z Hao / ; S J Li / ; H S Chang / ; S M Zhou / ; H Q Liang / ; S J Cao / ; J G Liu / ; J Yang / ; M Y Zhao / ; Y Lv / ; S L Xu / ; Z L Wang / ; S P Zhao / ; X P Li / ; X L Luo / ; Y P Li / ; Y Lei / ; S Q Fan / ; L H Wang / ; L J Zhao / ; Y C Zhao / ; S W Xue / ; J LI / ; S Y Xu / ; Y G Cao / ; B G Tong / ; W Wang / ; S K Xu / ; X F Jing / ; C H Wang / ; B X Tang / ; H Bai / ; L Li / ; Y Liu / ; Y P Li / ; F Mei / ; K Z Yuan / ; Y Zhang / ; Y R Sun / ; L Chen / ; S R Xue / ; J P Wang / ; B Li / ; Z M Liu / ; L H Shen / ; J R Liang / ; Y Zhang / ; Y L Song / ; Y M Sun / ; Z Wan / ; Y H Xu / ; W J Zhang / ; R Q Mu / ; K Q Li / ; Y P Wei / ; S M Wang / ; Y J Fan / ; K Y An / ; J Guo / ; A P Li / ; D Y Zeng / ; H Y Huo / ; Y Chen / ; L X Song / ; B Q Jiang / ; D J Guo / ; H Chen / ; L Li / ; Y Q Yin / ; Y M Mao / ; L Miao / ; Y J Guo / ; S J Li / ; S S Cui / ; Q Diao / ; X M You / ; B Jiang / ; L T Zhu / ; J M Liu / ; L Fang / ; S G Lin / ; L Y Chen / ; W H Huang / ; Z G Zheng / ; Y N Ke / ; Y Wang / ; Q S Wang / ; H Liang / ; R Y Jia / ; T Wang / ; C X Liu / ; Q J Geng / ; B X Duan / ; C Q Fang / ; J Y Wang / ; Z W Chang / ; Y Qi / ; X Wang / ; W S He / ; P Ye / ; Y C Liu / ; C Y Li / ; J J Ye / ; B X He / ; X Y Zhang / ; X F Hong / ; R G Shi / ; W L Wei / ; J J Sun / ; Z C Li / ; X J Zhang / ; P He / ; W Gao / ; Y He / ; H B Zhang / ; N D Li / ; X N He / ; G L Chen / ; J L Wang / ; G F Liang / ; G Z Dai / ; Q Wang / ; H Y Jin / ; S Wang /

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