Document Detail

Beneficial effects of treadmill training in a cerebral palsy-like rodent model: walking pattern and soleus quantitative histology.
MedLine Citation:
PMID:  18586228     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate whether treadmill locomotor training could have beneficial effects on deficits consequent to perinatal anoxia, sensorimotor restriction or a combination of both. Fifty-six newborn male Wistar rats were divided into four groups: control, anoxic, sensorimotor-restricted and anoxic-sensorimotor-restricted. Rats were exposed to anoxia in the first two postnatal days (P0 and P1) and/or hind-limb sensorimotor restriction from P2 to P28 for 16 h/day. Control and experimental rats underwent treadmill training for three weeks (from P31 to P52). Body weight and walking patterns (stride length and foot angle) were measured weekly during treadmill locomotor training. Soleus muscle cross-sectional mean area and fiber density were measured using planar morphometry. Anoxia per se did not cause gait or muscle deficits. Body weight, stride length and soleus fiber cross-sectional mean area, however, were increased in trained anoxic rats. Sensorimotor-restricted animals, either with or without perinatal anoxia, showed deficits in body weight gain, decreased stride length, wider foot angle and soleus fiber atrophy. In the sensorimotor-restricted group, treadmill training improved body weight gain and stride length, and decreased the percentage of the atrophic fibers. However, in the anoxic-sensorimotor-restricted group, training improved stride length only. Three weeks of treadmill training were able to improve stride length in restricted and anoxic-restricted animals, although body weight deficit and the degree of degradation in muscle histology were reduced only in the restricted group.
Simone Marcuzzo; Márcio Ferreira Dutra; Felipe Stigger; Patrícia Severo do Nascimento; Jocemar Ilha; Pedro Ivo Kalil-Gaspar; Matilde Achaval
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-27
Journal Detail:
Title:  Brain research     Volume:  1222     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-40     Citation Subset:  IM    
Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite 500, Porto Alegre, RS, Brazil.
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MeSH Terms
Age Factors
Analysis of Variance
Animals, Newborn
Behavior, Animal
Body Weight
Cerebral Palsy* / etiology,  pathology,  rehabilitation
Disease Models, Animal
Exercise Test
Muscle, Skeletal / pathology*
Physical Conditioning, Animal / methods*
Rats, Wistar
Restraint, Physical / methods
Walking / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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