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Beneficial effects of supplementation of branched-chain amino acids on postoperative bacteremia in living-donor liver transplantation recipients.
MedLine Citation:
PMID:  21542128     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study is to investigate the effects of preoperative oral supplementation of branched-chain amino acid (BCAA) on postoperative bacteremia following living-donor liver transplantation (LDLT) for chronic liver failure. Two hundred and thirty eight patients who underwent adult-to-adult LDLT were evaluated in this retrospective study. The patients divided into two groups; those who received preoperative oral supplementation of BCAAs (BCAA group, n=129) and those who did not (non-BCAA group, n=107). The BCAA supplementation has been prescribed for preserving hepatic reserve by hepatologist before the indication of LDLT has been determined. The clinical characteristics and incidence of bacteremia were compared between the two groups. In terms of clinical characteristics, Child-Pugh (P=0.0002) and the Model of End-stage Liver Disease (P=0.0010) scores were significantly higher in the BCAA group than in the non-BCAA group. Among patients with Child-Pugh score C, the incidence of bacteremia was significantly lower in the BCAA group than in the non-BCAA group. The incidence was 6of 92 patients (7%) in the BCAA groups and 11of 49 patients (22%) in the non-BCAA group, respectively, (P=0.0121). In multivariate analysis, non-BCAA supplementation was an independent risk of bacteremia. In conclusion, preoperative supplementation of BCAA might reduce the incidence of bacteremia after LDLT. Nevertheless, this is preliminary report and further study, such as randomized prospective study is necessary to clarify the benefitial effects of BCAA supplementation on postoperative bacteremia after liver transplantation. Liver Transpl, 2011. © 2011 AASLD.
Authors:
Ken Shirabe; Masanori Yoshimatsu; Takashi Motomura; Kazuki Takeishi; Takeo Toshima; Jun Muto; Rumi Matono; Akinobu Taketomi; Hideaki Uchiyama; Yoshihiko Maehara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-3
Journal Detail:
Title:  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society     Volume:  -     ISSN:  1527-6473     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909185     Medline TA:  Liver Transpl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Association for the Study of Liver Diseases.
Affiliation:
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. kshirabe@surg2.med.kyushu-u.ac.jp.
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