Document Detail

Beneficial effects of supplemental nitric oxide donor given during reperfusion period in reperfusion-induced lung injury.
MedLine Citation:
PMID:  17089316     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reperfusion injury is a perplexing cause of early graft failure after lung transplantation and today we know that reperfusion may be more harmful to tissues than the preceding ischemia. We hypothesized that administration of the nitric oxide donor nitroglycerin (NTG) during flush perfusion and reperfusion periods would ameliorate reperfusion-induced lung injury. METHODS: Using an IN SITU normothermic ischemic lung rabbit model, three groups were studied (n = 7/group): (1) NTG given during flush perfusion (ischemia group); (2) NTG given in the flush perfusion and the reperfusion period (reperfusion group); and (3) no NTG (control group). All groups were flushed with low potassium dextran glucose solution. Blood gas analysis, tissue nitrite (nitric oxide metabolite) level analysis, bronchoalveolar lavage (BAL) fluid examination and morphological examinations were performed. RESULTS: Compared with the ischemia group, the reperfusion group had significantly improved arterial oxygenation (318 +/- 31.4 mmHg vs. 180 +/- 14.7 mmHg, P < 0.05), decreased BAL fluid neutrophil percentage (21 +/- 1.9 % vs. 30 +/- 5.6 %, P < 0.05), increased tissue nitrite level (32.55 +/- 4.12 nmol/g vs. 27.81 +/- 1.05 nmol/g, P < 0.05), and decreased tissue histopathological lesion scores (0.42 +/- 0.53 vs. 1.14 +/- 0.37, P < 0.05). CONCLUSIONS: This study suggests that nitric oxide donors supplemented during flush perfusion and reperfusion have more beneficial effects on lung functions against reperfusion injury than any other treatment modalities during IN SITU normothermic ischemic lung model.
H Esme; H Fidan; O Solak; F H Dilek; R Demirel; M Unlu
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  54     ISSN:  0171-6425     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  477-83     Citation Subset:  IM    
Department of Thoracic Surgery, Kocatepe University School of Medicine, Afyon, Turkey.
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MeSH Terms
Analysis of Variance
Heart-Lung Transplantation
Lung / blood supply,  pathology
Lung Transplantation*
Neutrophils / metabolism
Nitric Oxide Donors / therapeutic use*
Nitrites / metabolism
Nitroglycerin / therapeutic use*
Reperfusion Injury / prevention & control*
Respiratory Distress Syndrome, Adult / prevention & control*
Reg. No./Substance:
0/Nitric Oxide Donors; 0/Nitrites; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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