| Beneficial effects of supplemental nitric oxide donor given during reperfusion period in reperfusion-induced lung injury. | |
| | |
MedLine Citation:
|
PMID: 17089316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Reperfusion injury is a perplexing cause of early graft failure after lung transplantation and today we know that reperfusion may be more harmful to tissues than the preceding ischemia. We hypothesized that administration of the nitric oxide donor nitroglycerin (NTG) during flush perfusion and reperfusion periods would ameliorate reperfusion-induced lung injury. METHODS: Using an IN SITU normothermic ischemic lung rabbit model, three groups were studied (n = 7/group): (1) NTG given during flush perfusion (ischemia group); (2) NTG given in the flush perfusion and the reperfusion period (reperfusion group); and (3) no NTG (control group). All groups were flushed with low potassium dextran glucose solution. Blood gas analysis, tissue nitrite (nitric oxide metabolite) level analysis, bronchoalveolar lavage (BAL) fluid examination and morphological examinations were performed. RESULTS: Compared with the ischemia group, the reperfusion group had significantly improved arterial oxygenation (318 +/- 31.4 mmHg vs. 180 +/- 14.7 mmHg, P < 0.05), decreased BAL fluid neutrophil percentage (21 +/- 1.9 % vs. 30 +/- 5.6 %, P < 0.05), increased tissue nitrite level (32.55 +/- 4.12 nmol/g vs. 27.81 +/- 1.05 nmol/g, P < 0.05), and decreased tissue histopathological lesion scores (0.42 +/- 0.53 vs. 1.14 +/- 0.37, P < 0.05). CONCLUSIONS: This study suggests that nitric oxide donors supplemented during flush perfusion and reperfusion have more beneficial effects on lung functions against reperfusion injury than any other treatment modalities during IN SITU normothermic ischemic lung model. |
| | |
Authors:
|
H Esme; H Fidan; O Solak; F H Dilek; R Demirel; M Unlu |
Related Documents
:
|
17362896 - Gap junctional uncoupling plays a trigger role in the antiarrhythmic effect of ischaemi... 12493506 - The effect of aprotinin on ischemia-reperfusion injury in an in situ normothermic ische... 11683676 - Pre-conditioning activates adenosine utilization in a cost-effective way during myocard... 9692436 - Retrograde cerebral perfusion enhances cerebral protection during prolonged hypothermic... 15596746 - Effects of a 6-month exercise program on patients with multiple sclerosis: a randomized... 12907536 - Peak physiologic responses to arm and leg ergometry in male and female patients with ai... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article |
Journal Detail:
|
Title: The Thoracic and cardiovascular surgeon Volume: 54 ISSN: 0171-6425 ISO Abbreviation: Thorac Cardiovasc Surg Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-11-07 Completed Date: 2007-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903387 Medline TA: Thorac Cardiovasc Surg Country: Germany |
Other Details:
|
Languages: eng Pagination: 477-83 Citation Subset: IM |
Affiliation:
|
Department of Thoracic Surgery, Kocatepe University School of Medicine, Afyon, Turkey. hesme@aku.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Heart-Lung Transplantation Lung / blood supply, pathology Lung Transplantation* Neutrophils / metabolism Nitric Oxide Donors / therapeutic use* Nitrites / metabolism Nitroglycerin / therapeutic use* Rabbits Reperfusion Injury / prevention & control* Respiratory Distress Syndrome, Adult / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Nitric Oxide Donors; 0/Nitrites; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidental diagnosis of a left ventricular thrombus through novel magnetic resonance imaging techniq...
Next Document: Pulmonary metastasectomy following chemotherapy in patients with testicular tumors: experience in 52...