| Beneficial effects of a single dose of quinapril on left ventricular performance in chronic mitral regurgitation. | |
| | |
MedLine Citation:
|
PMID: 8160617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To evaluate the effect of a single dose of the angiotensin-converting enzyme inhibitor quinapril on left ventricular (LV) performance and size in patients with moderate to severe chronic mitral regurgitation (MR), 12 patients with angiographically proven isolated MR grade II to III and no evidence of coronary artery disease were studied. In all patients a baseline right heart catheterization and simultaneous radionuclide angiogram were performed at rest and during supine exercise (maximum 100 W) as well as 2 hours after oral administration of 10 mg of quinapril. Quinapril reduced heart rate slightly and lowered mean blood pressure at rest and during maximal exercise (p < 0.05). Systemic vascular resistance at rest was decreased from 1,484 +/- 505 to 1,150 +/- 427 dynes s cm-5 and with maximal exercise from 999 +/- 455 to 734 +/- 395 dynes s cm-5 (p < 0.005). Pulmonary capillary arterial pressure at rest decreased from 13 +/- 6 to 10 +/- 4 mm Hg (p = 0.01) and during maximal exercise from 29 +/- 10 to 20 +/- 7 mm Hg (p = 0.001). LV end-diastolic volume at rest (146 +/- 26 ml/m2) decreased after administration of quinapril to 128 +/- 24 ml/m2 (p = 0.001) and was also reduced during exercise (p = 0.001). LV end-systolic volume decreased from 63 +/- 43 to 49 +/- 35 ml/m2 at rest (p = 0.001) and with maximal exercise from 56 +/- 49 to 44 +/- 39 ml/m2 (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
H R Schön; G Schröter; H Blömer; A Schömig |
Related Documents
:
|
22849607 - A 12-week after-school physical activity programme improves endothelial cell function i... 17496217 - Contribution of mitral annular dynamics to lv diastolic filling with alteration in prel... 14609517 - The effects of cycle racing on pulmonary diffusion capacity and left ventricular systol... 19767797 - Effects of the self-contained breathing apparatus on left-ventricular function at rest ... 21068567 - Sickle cell trait in sports. 3767037 - Noninvasive evaluation of breathing pattern and thoraco-abdominal motion following the ... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: The American journal of cardiology Volume: 73 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1994 Apr |
Date Detail:
|
Created Date: 1994-05-19 Completed Date: 1994-05-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 785-91 Citation Subset: AIM; IM |
Affiliation:
|
I. Med. Klinik, Technische University München, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Angiotensin-Converting Enzyme Inhibitors / administration & dosage*, pharmacology, therapeutic use Chronic Disease Female Hemodynamics / drug effects Humans Isoquinolines / administration & dosage*, pharmacology, therapeutic use Male Middle Aged Mitral Valve Insufficiency / drug therapy*, physiopathology Tetrahydroisoquinolines* Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 82586-55-8/quinapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of cessation of caffeinated-coffee consumption on ambulatory and resting blood pressure in m...
Next Document: Prognostic value of Doppler echocardiographic assessment of left ventricular filling in idiopathic d...