Document Detail


Beneficial effects of a single dose of quinapril on left ventricular performance in chronic mitral regurgitation.
MedLine Citation:
PMID:  8160617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the effect of a single dose of the angiotensin-converting enzyme inhibitor quinapril on left ventricular (LV) performance and size in patients with moderate to severe chronic mitral regurgitation (MR), 12 patients with angiographically proven isolated MR grade II to III and no evidence of coronary artery disease were studied. In all patients a baseline right heart catheterization and simultaneous radionuclide angiogram were performed at rest and during supine exercise (maximum 100 W) as well as 2 hours after oral administration of 10 mg of quinapril. Quinapril reduced heart rate slightly and lowered mean blood pressure at rest and during maximal exercise (p < 0.05). Systemic vascular resistance at rest was decreased from 1,484 +/- 505 to 1,150 +/- 427 dynes s cm-5 and with maximal exercise from 999 +/- 455 to 734 +/- 395 dynes s cm-5 (p < 0.005). Pulmonary capillary arterial pressure at rest decreased from 13 +/- 6 to 10 +/- 4 mm Hg (p = 0.01) and during maximal exercise from 29 +/- 10 to 20 +/- 7 mm Hg (p = 0.001). LV end-diastolic volume at rest (146 +/- 26 ml/m2) decreased after administration of quinapril to 128 +/- 24 ml/m2 (p = 0.001) and was also reduced during exercise (p = 0.001). LV end-systolic volume decreased from 63 +/- 43 to 49 +/- 35 ml/m2 at rest (p = 0.001) and with maximal exercise from 56 +/- 49 to 44 +/- 39 ml/m2 (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H R Schön; G Schröter; H Blömer; A Schömig
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  73     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  785-91     Citation Subset:  AIM; IM    
Affiliation:
I. Med. Klinik, Technische University München, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*,  pharmacology,  therapeutic use
Chronic Disease
Female
Hemodynamics / drug effects
Humans
Isoquinolines / administration & dosage*,  pharmacology,  therapeutic use
Male
Middle Aged
Mitral Valve Insufficiency / drug therapy*,  physiopathology
Tetrahydroisoquinolines*
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 82586-55-8/quinapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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