| Beneficial effects of selenium on some enzymes of diabetic rat heart. | |
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MedLine Citation:
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PMID: 15784954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is known that selenium compounds can restore some metabolic parameters in experimental diabetes. However, as there are no clear data about their effects on the altered antioxidant defense system of the diabetic heart, we aimed to investigate whether these beneficial effects extend to the alterations of some enzyme activities, which play important roles in antioxidant defense system. Diabetes was induced by streptozotocin (50 mg/kg body weight) and rats were then treated with sodium selenite (5 micromol/kg/d) for 4 wk. Sodium selenite treatment of the diabetic rats significantly restored the altered activities of glutathione-S-transferase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase, which are involved in the glutathione metabolism of the heart, but slightly but significantly decreased the high blood glucose level. In summary, the present study suggests that the beneficial effects of sodium selenite treatment appears to be the result of the restoration altered activities of the antioxidant enzymes in diabetic heart tissue. |
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Authors:
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Nuriye Nuray Ulusu; Belma Turan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological trace element research Volume: 103 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-23 Completed Date: 2005-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 207-16 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Body Weight Diabetes Mellitus, Experimental / metabolism* Female Glucosephosphate Dehydrogenase / metabolism Glutathione Transferase / metabolism Male Myocardium / enzymology* Phosphogluconate Dehydrogenase / metabolism Random Allocation Rats Rats, Wistar Sodium Selenite / administration & dosage, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 10102-18-8/Sodium Selenite; EC 1.1.1.43/Phosphogluconate Dehydrogenase; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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