| Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed a high-fat diet. | |
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MedLine Citation:
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PMID: 22420611 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study aimed to evaluate the effects of rosuvastatin (ST) and rosiglitazone (GZ) on insulin resistance (IR) and on liver as well as adipose tissue in mice fed a high-fat (HF) diet. Our data show that treatment with rosuvastatin resulted in a marked improvement in insulin sensitivity characterised by enhanced glucose clearance during insulin tolerance test and a 70% decrease in the HOMA-IR index level (P=0.0008). The rosuvastatin-treated mice exhibited lower gains in body mass (-8%; P<0.01) and visceral fat pad thickness (-60%; P<0.01) compared with the untreated HF group. In comparison with HF mice, HF+ST-treated mice showed a significant reduction in hepatomegaly and liver steatosis (-6%; P<0.05 and -21%; P<0.01, respectively). In HF+ST-treated mice, the hepatic triglyceride levels were reduced by 58% compared with the HF group (P <0.01). In addition, the expression of SREBP1 (sterol regulatory element-binding protein) was decreased by 50% in the livers of HF+ST-treated mice (P<0.01) relative to the HF mice. The levels of resistin were lower in the HF+ST-treated group compared with the HF group (44% less, P< 0.01). In conclusion, we demonstrated that rosuvastatin treatment improved insulin sensitivity and decreased liver steatosis in mice fed a high-fat diet. Furthermore, rosuvastatin reduced body mass gains, improved the circulating levels of plasma cholesterol and triglycerides, and reduced hepatic triglycerides, which was concomitant with lower resistin. |
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Authors:
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Julio Cesar Fraulob; Vanessa Souza-Mello; Marcia Barbosa Aguila; Carlos A Mandarim-de-Lacerda |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-15 |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: - ISSN: 1470-8736 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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