| Beneficial effects of regular exercise on sleep in old F344 rats. | |
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MedLine Citation:
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PMID: 16309796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With aging there is a significant decline in the normal architecture of sleep and a reduction in the diurnal amplitude of core body temperature. Regular moderate exercise has been shown to have a positive impact in the elderly and here we investigate whether sleep-wake patterning can also be improved. Young (3 months) and old (22 months) F344 rats were exercised once a day for 50min at night onset over an 8-week period. Thereafter, polysomnographic recordings were obtained immediately after exercise. To determine the lasting consequences of exercise, sleep was also recorded 2 days and 2 weeks after exercise had ended. Old rats that were exercised had a significant weight loss, were awake more during the last third of their active period, had less sleep fragmentation and the amplitude of the diurnal rhythm of core body temperature was significantly increased. Old exercised rats also had an overall increase in the amplitude of EEG power (0.5-16Hz) during wake and theta EEG power during REM sleep. In young rats regular exercise increased EEG delta power (0.5-4Hz) during NREM sleep. Our data indicate regular exercise in old rats improves sleep architecture, EEG power and diurnal rhythm of temperature. |
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Authors:
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C A Blanco-Centurion; P J Shiromani |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2005-11-23 |
Journal Detail:
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Title: Neurobiology of aging Volume: 27 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-10-23 Completed Date: 2007-01-03 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 1859-69 Citation Subset: IM |
Affiliation:
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West Roxbury Veterans Medical Center and Harvard Medical School, West Roxbury, MA 02132, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Body Temperature / physiology Electroencephalography Male Physical Conditioning, Animal / physiology* Rats Rats, Inbred F344 Sleep / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AG 09975/AG/NIA NIH HHS; AG 15853/AG/NIA NIH HHS; MH 55772/MH/NIMH NIH HHS; NS 30140/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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