Document Detail


Beneficial effects of the prostacyclin analogue taprostene on cardiovascular, pulmonary and renal disturbances in endotoxin-shocked rabbits.
MedLine Citation:
PMID:  1910868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prostacyclin analogue taprostene protects against lethal endotoxemia in rats. In the present study, the effects of taprostene on endotoxin-induced cardiovascular, pulmonary and renal alterations have been investigated. In anesthetized rabbits, infusion of 0.5 mg/kg Escherichia coli lipopolysaccharide i.v. over 30 min produced systemic hypotension, pulmonary hypertension, and decreases in cardiac output, peripheral oxygen delivery and renal glomerular filtration rate. In endotoxemic rabbits treated with taprostene (0.2 micrograms.kg-1.min-1 i.v. over 180 min), the blood pressure tended to be lower than in untreated endotoxemic controls. Taprostene reduced the total peripheral resistance and abolished the endotoxin-induced increases in pulmonary artery pressure and resistance. Taprostene prevented the decreases in cardiac output and peripheral oxygen supply. At the end of the experiment the glomerular filtration rate was higher in taprostene-treated than in untreated endotoxemic rabbits and did not differ significantly from that in non-endotoxemic controls. The results show that taprostene prevents the pulmonary hypertension, preserves cardiac output and peripheral oxygen delivery, and substantially maintains the glomerular filtration rate in endotoxin-shocked rabbits.
Authors:
J Schneider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eicosanoids     Volume:  4     ISSN:  0934-9820     ISO Abbreviation:  Eicosanoids     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-01     Completed Date:  1991-11-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8906009     Medline TA:  Eicosanoids     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Grünenthal GmbH, Aachen, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cardiovascular Agents / pharmacology*
Endotoxins / pharmacology*
Epoprostenol / analogs & derivatives*,  pharmacology
Heart / drug effects*
Heart Rate / drug effects
Kidney / drug effects*
Lung / drug effects*
Male
Rabbits
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 0/Endotoxins; 35121-78-9/Epoprostenol; 87440-45-7/taprostene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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