| Beneficial effects of prolonged systemic administration of PlGF on late outcome of post-ischaemic myocardial performance. | |
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MedLine Citation:
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PMID: 18729077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence indicates that an imbalance between cardiomyocyte hypertrophy and blood vessel growth in the remote myocardium may contribute to heart failure in ischaemic heart disease. It remains, however, largely unknown which angiogenic factors are capable of stimulating vessel growth in the remote myocardium after myocardial infarction (MI) and whether systemic, rather than local, administration of such factors suffices to ameliorate post-MI cardiac recovery. We therefore analysed the effect of systemic placental growth factor (PlGF) delivery on myocardial recovery post-MI in mice. MI was induced by permanent ligation of the left anterior descending coronary (LAD) artery in C57Bl6/J mice, followed by systemic injection of a PlGF adenovirus, resulting in elevated circulating levels of PlGF for 4 weeks. Functional and morphological analysis revealed that PlGF treatment induced cardiomyocyte hypertrophy and improved cardiac recovery at day 28 post-MI. PlGF stimulated angiogenesis in the infarct border and vessel enlargement in the remote myocardium. In this mouse model, capillary-to-cardiomyocyte ratios in the remote myocardium were maintained post-MI, but PlGF increased the vascular perfusion area in balance with the cardiomyocyte hypertrophy. Overall, systemic delivery of PlGF improves cardiac performance and promotes adaptive remodelling of the post-MI heart. |
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Authors:
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C Roncal; I Buysschaert; Ek Chorianopoulos; M Georgiadou; O Meilhac; M Demol; J-B Michel; S Vinckier; L Moons; P Carmeliet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pathology Volume: 216 ISSN: 1096-9896 ISO Abbreviation: J. Pathol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2008-10-21 Revised Date: 2009-11-25 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
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Languages: eng Pagination: 236-44 Citation Subset: IM |
Affiliation:
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Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics* Analysis of Variance Animals Coronary Vessels / pathology Echocardiography Female Gene Therapy / methods* Ligation Mice Mice, Inbred C57BL Models, Animal Myocardial Infarction / metabolism*, pathology Myocardium / metabolism*, pathology Pregnancy Proteins / genetics* Time Transduction, Genetic / methods |
| Chemical | |
Reg. No./Substance:
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0/Pregnancy Proteins; 144589-93-5/placenta growth factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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