| Beneficial effects of preoperative intravitreal bevacizumab on trabeculectomy outcomes in neovascular glaucoma. | |
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MedLine Citation:
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PMID: 19775309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study aimed to investigate the effects of preoperative intravitreal bevacizumab (IVB) on outcomes in trabeculectomy for neovascular glaucoma (NVG). METHODS: Charts for 52 NVG eyes of 52 consecutive patients who received primary trabeculectomy with mitomycin C (MMC) were reviewed. Postoperative follow-up periods for all patients were > or = 4 months. Thirty-two consecutive eyes were treated without IVB (control group) and 20 consecutive eyes received IVB (1.25 mg) 10 +/- 11 days before trabeculectomy (IVB group). The main outcome measures were postoperative intraocular pressure (IOP) and incidence of postoperative complications. Surgical success was defined as IOP< 21 mmHg with or without medication (qualified or complete success, respectively). Failure was defined as IOP exceeding these criteria, phthisis bulbi, loss of light perception or additional glaucoma surgeries. Kaplan-Meier survival analysis with the log-rank test was performed to compare surgical success rates between the two groups. RESULTS: Complete and qualified success rates at 6 months were 95% versus 50% and 95% versus 75% in the IVB and control groups, respectively. The IVB group achieved significantly better surgical success rates than the control group (complete success, p < 0.001; qualified success, p = 0.026). Postoperative hyphaema on day 1 or hyphaema with a duration of > 1 week occurred significantly less frequently in the IVB group than in the control group (p = 0.009, p = 0.014, respectively). The incidence of serious complications such as endophthalmitis, phthisis bulbi and a marked decrease in visual acuity did not increase in the IVB group. CONCLUSIONS: This retrospective study showed that preoperative IVB decreased postoperative hyphaema and increased surgical success rates, and thus may be an effective adjunct to trabeculectomy in NVG. |
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Authors:
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Yoshiaki Saito; Tomomi Higashide; Hisashi Takeda; Shinji Ohkubo; Kazuhisa Sugiyama |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2009-09-23 |
Journal Detail:
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Title: Acta ophthalmologica Volume: 88 ISSN: 1755-3768 ISO Abbreviation: Acta Ophthalmol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-05-27 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 101468102 Medline TA: Acta Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 96-102 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Takara-machi, Kanazawa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anterior Chamber / blood supply Antibodies, Monoclonal / administration & dosage* Antibodies, Monoclonal, Humanized Choroid Hemorrhage / etiology Eye Hemorrhage / etiology Female Follow-Up Studies Glaucoma, Neovascular / physiopathology, surgery* Humans Hyphema / prevention & control Injections, Intraocular Intraocular Pressure / drug effects Male Middle Aged Mitomycin / therapeutic use Postoperative Complications / prevention & control Postoperative Period Preoperative Care* / standards Recurrence Retrospective Studies Trabeculectomy* / adverse effects Treatment Outcome Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V/bevacizumab; 50-07-7/Mitomycin |
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