Document Detail

Beneficial effects of preoperative intravitreal bevacizumab on trabeculectomy outcomes in neovascular glaucoma.
MedLine Citation:
PMID:  19775309     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study aimed to investigate the effects of preoperative intravitreal bevacizumab (IVB) on outcomes in trabeculectomy for neovascular glaucoma (NVG).
METHODS: Charts for 52 NVG eyes of 52 consecutive patients who received primary trabeculectomy with mitomycin C (MMC) were reviewed. Postoperative follow-up periods for all patients were > or = 4 months. Thirty-two consecutive eyes were treated without IVB (control group) and 20 consecutive eyes received IVB (1.25 mg) 10 +/- 11 days before trabeculectomy (IVB group). The main outcome measures were postoperative intraocular pressure (IOP) and incidence of postoperative complications. Surgical success was defined as IOP< 21 mmHg with or without medication (qualified or complete success, respectively). Failure was defined as IOP exceeding these criteria, phthisis bulbi, loss of light perception or additional glaucoma surgeries. Kaplan-Meier survival analysis with the log-rank test was performed to compare surgical success rates between the two groups.
RESULTS: Complete and qualified success rates at 6 months were 95% versus 50% and 95% versus 75% in the IVB and control groups, respectively. The IVB group achieved significantly better surgical success rates than the control group (complete success, p < 0.001; qualified success, p = 0.026). Postoperative hyphaema on day 1 or hyphaema with a duration of > 1 week occurred significantly less frequently in the IVB group than in the control group (p = 0.009, p = 0.014, respectively). The incidence of serious complications such as endophthalmitis, phthisis bulbi and a marked decrease in visual acuity did not increase in the IVB group.
CONCLUSIONS: This retrospective study showed that preoperative IVB decreased postoperative hyphaema and increased surgical success rates, and thus may be an effective adjunct to trabeculectomy in NVG.
Yoshiaki Saito; Tomomi Higashide; Hisashi Takeda; Shinji Ohkubo; Kazuhisa Sugiyama
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2009-09-23
Journal Detail:
Title:  Acta ophthalmologica     Volume:  88     ISSN:  1755-3768     ISO Abbreviation:  Acta Ophthalmol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-05-27     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM    
Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Takara-machi, Kanazawa, Japan.
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MeSH Terms
Anterior Chamber / blood supply
Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal, Humanized
Choroid Hemorrhage / etiology
Eye Hemorrhage / etiology
Follow-Up Studies
Glaucoma, Neovascular / physiopathology,  surgery*
Hyphema / prevention & control
Injections, Intraocular
Intraocular Pressure / drug effects
Middle Aged
Mitomycin / therapeutic use
Postoperative Complications / prevention & control
Postoperative Period
Preoperative Care* / standards
Retrospective Studies
Trabeculectomy* / adverse effects
Treatment Outcome
Vitreous Body
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V/bevacizumab; 50-07-7/Mitomycin

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