Document Detail

Beneficial effects of oxfenicine on the hypoxic rat atria.
MedLine Citation:
PMID:  8574776     Owner:  NLM     Status:  MEDLINE    
During hypoxia the isolated rat atria released lactate into the bathing medium and underwent a rise of resting tension and a decline of the peak developed tension and pacemaker frequency. The atria from 24 h fasted rats, which oxidize faster their endogenous triacylglycerol pool, showed greater functional disturbances during hypoxia and a smaller recovery after reoxygenation than those from fed rats. Oxfenicine, which is a selective inhibitor of carnitine palmitoyltransferase I, attenuated the rise of resting tension and improved the post-hypoxic recovery of peak tension in the atria from fasted rats. The decline of the pacemaker frequency as well as the lactate output were not altered by the inhibitor. Present data show that oxfenicine ameliorated some of the hypoxic functional disturbances. Inasmuch lactate output did not change and these effects manifested only in the atria predisposed to the utilization of endogenous lipids, it may be inferred that oxfenicine preserved the atrial functions through the inhibition of fatty acid oxidation.
M Carregal; A Varela; V Dalamon; S Sacks; E A Savino
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of physiology and biochemistry     Volume:  103     ISSN:  1381-3455     ISO Abbreviation:  Arch. Physiol. Biochem.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1996-03-11     Completed Date:  1996-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9510153     Medline TA:  Arch Physiol Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Cátedra de Fisiología, Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
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MeSH Terms
Atrial Function
Carnitine O-Palmitoyltransferase / antagonists & inhibitors
Enzyme Inhibitors / pharmacology
Glycine / analogs & derivatives*,  pharmacology
Heart / drug effects,  physiology*
Heart Atria / drug effects
Heart Rate / drug effects
Myocardial Contraction / drug effects
Oxygen / administration & dosage*
Triglycerides / metabolism
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Triglycerides; 56-40-6/Glycine; 7782-44-7/Oxygen; 938-97-6/4-hydroxyphenylglycine; EC O-Palmitoyltransferase

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