Document Detail

Beneficial effects of nitric oxide on cardiac diastolic function: 'the flip side of the coin'.
MedLine Citation:
PMID:  11498647     Owner:  NLM     Status:  MEDLINE    
Modulation by NO of systolic myocardial function received widespread attention but most studies focused on potential negative inotropic properties of NO. The very original observations on the effects of NO on myocardial contraction already provided evidence that NO modified myocardial contractile performance mainly through a relaxation-hastening effect (i.e. earlier onset of relaxation) and through an increase in myocardial distensibility. The present review discusses the relaxation hastening and distensibility-increasing effects of NO in experimental preparations, in the normal human heart, in left ventricular hypertrophy of aortic stenosis, in the human allograft and in dilated nonischemic cardiomyopathy. This 'diastolic flip side' of the myocardial effects of NO appears to be beneficial especially for patients who are dependent on the LV Frank-Starling response to maintain cardiac output.
W J Paulus
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Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  Heart failure reviews     Volume:  5     ISSN:  1382-4147     ISO Abbreviation:  Heart Fail Rev     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-08-10     Completed Date:  2001-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9612481     Medline TA:  Heart Fail Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-44     Citation Subset:  IM    
Cardiovascular Center, O.L.V. Ziekenhuis, Aalst, Belgium.
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MeSH Terms
Cardiomyopathies / physiopathology
Diastole / drug effects,  physiology
Heart Transplantation / physiology
Hypertrophy, Left Ventricular / physiopathology
Myocardial Contraction / drug effects*,  physiology
Nitric Oxide / pharmacology*,  physiology
Ventricular Function, Left / drug effects
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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