Document Detail

Beneficial effects of nifedipine on regional myocardial blood flow in patients with coronary artery disease.
MedLine Citation:
PMID:  7053296     Owner:  NLM     Status:  MEDLINE    
Nifedipine inhibits the slow-channel calcium current, which plays a major role in vascular smooth-muscle contraction. However, the effect of nifedipine on regional myocardial blood flow (RMBF) in patients with coronary artery disease (CAD) is unknown. In 18 patients with chest pain syndromes, RMBF was determined with xenon-133 before and after nifedipine. In patients with CAD. 25 regions were analyzed distal to significant coronary obstruction(greater than 70% reduction in luminal diameter) and eight regions were analyzed in patients with normal coronary arteries. In patients with CAD, RMBF increased in 21 of 25 regions (average 17.4 /+- 5.7%,p less than 0.01), but decreased in all eight regions in patients with normal coronary arteries, by an average of 14.4 /+- 2.3% (p less than 0.01). The difference between groups was significant (p less than 0.01). In our patients with CAD, improved RMBF appears to be related to a decrease in coronary vascular tone and suggests a physiologic basis for the beneficial effect of nifedipine in ischemic heart disease.
R F Malacoff; B H Lorell; G H Mudge; B L Holman; J Idoine; L Bifolck; P F Cohn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  65     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I32-7     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / physiopathology
Coronary Circulation / drug effects*
Coronary Disease / drug therapy*
Heart Catheterization
Middle Aged
Nifedipine / therapeutic use*
Pyridines / therapeutic use*
Vascular Resistance / drug effects
Grant Support
Reg. No./Substance:
0/Pyridines; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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