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Beneficial effects of nebivolol treatment on oxidative stress parameters in patients with slow coronary flow.
MedLine Citation:
PMID:  20935430     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: Imbalance between oxidative stress and antioxidant defense has been demonstrated in patients with slow coronary flow (SCF). The aim of this study was to investigate the effect of nebivolol treatment on oxidative stress parameters in SCF patients.
STUDY DESIGN: The study included 32 patients (10 females, 22 males; mean age 53.3±5.2 years) with SCF and 32 control subjects (14 females, 18 males; mean age 50.6±5.2 years) with normal coronary arteries on angiography. Coronary slow flow was determined by the TIMI frame count method. Patients with SCF received nebivolol treatment (5 mg/day) for six months. Blood samples were analyzed for malondialdehyde (MDA) and serum nitric oxide (NO) levels, and erythrocyte catalase (CAT) and erythrocyte superoxide dismutase (SOD) activities in the control group and, in SCF patients, at baseline and after six months of nebivolol treatment.
RESULTS: The two groups were similar with respect to age, body mass index, blood pressure, heart rate, and lipid profile. Smoking was more frequent in the SCF group compared to the controls. TIMI frame counts measured from the left anterior descending, circumflex, and right coronary arteries were significantly higher in the SCF group (p<0.0001). Baseline MDA and NO levels, and SOD and CAT activities were significantly different between the two groups, with significantly increased MDA (p<0.0001), and significantly decreased SOD (p<0.0001), CAT (p<0.001), and NO (p<0.001) in the SCF group. After six months of nebivolol treatment, all oxidative stress parameters showed significant improvements compared to the baseline values (p<0.0001 for MDA, SOD, CAT, and NO) and approximated to the values of the control group.
CONCLUSION: Our results show that nebivolol treatment may be beneficial to improve oxidative stress parameters in patients with SCF, which are considered to be an early stage of atherosclerosis.
Ahmet Akçay; Gürkan Acar; Ergül Kurutaş; Abdullah Sökmen; Yalçın Atlı; Alper Buğra Nacar; Cemal Tuncer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır     Volume:  38     ISSN:  1016-5169     ISO Abbreviation:  Turk Kardiyol Dern Ars     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426239     Medline TA:  Turk Kardiyol Dern Ars     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  IM    
Department of Cardiology, Medicine Faculty of Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey.
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