Document Detail

Beneficial effects of metolazone in a rat model of preeclampsia.
MedLine Citation:
PMID:  16717105     Owner:  NLM     Status:  MEDLINE    
Preeclampsia is a disorder that continues to exact a significant toll with respect to maternal morbidity and mortality as well as fetal wastage. Furthermore, the treatment of this disorder has not changed significantly in 50 years and is unsatisfactory. The use of diuretics in this syndrome is controversial because there is a concern related to potential baleful effects of volume contraction leading to a possible further decrement in the perfusion of the maternal-fetal unit. Metolazone is a diuretic/antihypertensive agent, which has a therapeutic effect on blood pressure (BP) in human essential hypertension without causing a natriuresis. We administered the drug in nondiuretic doses in a rat model of preeclampsia previously developed in this laboratory. The drug reduced BP without an accompanying natriuresis. Although there was a trend toward an improvement in intrauterine growth restriction, as determined by litter size and the number of pups demonstrating malformations, the values did not reach statistical significance. We conclude that metolazone, in low dosage, is an effective antihypertensive in this rat model. These studies have implications for the treatment of the human disorder.
Gabriella Pridjian; Candice Pridjian; Svitlana Danchuk; Monica Ianosi-Irimie; Hop V Vu; Jules B Puschett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-22
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  318     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1027-32     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Tulane University School of Medicine, New Orleans, LA 70112-2699, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Disease Models, Animal
Metolazone / therapeutic use*
Nitric Oxide / blood,  urine
Pre-Eclampsia / drug therapy*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Antihypertensive Agents; 10102-43-9/Nitric Oxide; 17560-51-9/Metolazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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