Document Detail

Beneficial effects of hypertonic mannitol in acute ischemia--reperfusion injuries in humans.
MedLine Citation:
PMID:  8634857     Owner:  NLM     Status:  MEDLINE    
Acute ischemia-reperfusion of extremities is characterized by edema, compartment syndrome and neuromuscular dysfunction. Intravenous hypertonic mannitol has been shown to be of benefit in several experimental models. The authors' 5-year experience with the use of hypertonic mannitol and the treatment of acute ischemia reperfusion injuries in humans has been reviewed. Some of 186 patients with acute arterial occlusion following thromboembolism (149) and trauma (37) were treated. Hypertonic mannitol (25 g intravenous bolus followed by 5-10 g intravenous/h) was given perioperatively. Length of preoperative ischemia varied from 1 to 24h. Some of 57.5% of patients had preoperative neuromuscular dysfunction. Following revascularization, limb salvage was obtained in 97.7% of surviving patients and neuromuscular dysfunction improved in 89%. Overall, 15% required fasciotomy. The mortality rate was 3.2%. These data suggest that hypertonic mannitol may have some protective effect in acute ischemia-reperfusion injuries of human extremities. It may decrease the need for fasciotomy and minimize neuromuscular dysfunction.
D M Shah; D E Bock; R C Darling; B B Chang; A M Kupinski; R P Leather
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  4     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-07-08     Completed Date:  1996-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
Vascular Surgery Section, Albany Medical College, New York 12208, USA.
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MeSH Terms
Aged, 80 and over
Arterial Occlusive Diseases / drug therapy,  etiology,  surgery
Child, Preschool
Compartment Syndromes / drug therapy,  etiology,  surgery
Edema / drug therapy,  etiology,  surgery
Fascia / surgery
Hypertonic Solutions / administration & dosage,  therapeutic use*
Infusions, Intravenous
Injections, Intravenous
Ischemia / drug therapy*,  etiology
Leg / blood supply*
Leg Injuries / complications
Mannitol / administration & dosage,  therapeutic use*
Middle Aged
Neuromuscular Diseases / drug therapy,  etiology,  surgery
Reperfusion Injury / drug therapy*
Survival Rate
Thromboembolism / complications
Reg. No./Substance:
0/Hypertonic Solutions; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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