Document Detail


Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats.
MedLine Citation:
PMID:  17761920     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the growth factors regulating hematopoiesis. We have previously observed that SCF and G-CSF have neuroprotective and functional effects on acute brain ischemia. In the present study, the beneficial effects of SCF and G-CSF on chronic brain ischemia were determined. METHODS: SCF, G-CSF, or SCF+G-CSF was administered subcutaneously to rats 3.5 months after induction of ischemic stroke by middle cerebral artery occlusion. Neurological deficits were evaluated by limb placement test and foot fault test over time. Field-evoked potential was performed 19 weeks after treatment. Infarct volume was histologically determined using serial coronal sections. RESULTS: Significant functional improvement was seen in SCF+G-CSF-treated rats 1, 5, and 17 weeks after injections. SCF alone also improved functional outcome, but it did not show as stable improvement as SCF+G-CSF. No functional benefit was seen in G-CSF-treated rats. Field-evoked potential studies further confirmed the behavioral data that the normal pattern of neuronal activity was reestablished in the lesioned brain of the rats with good functional outcome. Interestingly, infarction volume was also significantly reduced in SCF+G-CSF-treated rats. CONCLUSIONS: These data provide first evidence that functional restoration in chronic brain ischemia can be attained using hematopoietic growth factors.
Authors:
Li-Ru Zhao; Hector H Berra; Wei-Ming Duan; Seema Singhal; Jayesh Mehta; A Vania Apkarian; John A Kessler
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-08-30
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  38     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2804-11     Citation Subset:  IM    
Affiliation:
Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Ill, USA. lzhao@lsuhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / drug therapy*,  pathology
Chronic Disease
Disease Models, Animal
Evoked Potentials, Somatosensory / drug effects
Granulocyte Colony-Stimulating Factor / pharmacology*
Male
Motor Activity / drug effects
Rats
Rats, Inbred SHR
Recovery of Function / drug effects*
Stem Cell Factor / pharmacology*
Stroke / drug therapy*,  pathology
Grant Support
ID/Acronym/Agency:
R01 NS20013/NS/NINDS NIH HHS; R01 NS20778/NS/NINDS NIH HHS; R01 NS34758/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Stem Cell Factor; 143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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