Document Detail


Beneficial effects of growth hormone and insulin-like growth factor-1 in experimental heart failure in rats treated with chronic ACE inhibition.
MedLine Citation:
PMID:  8583784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of growth hormone (GH) plus insulin-like growth factor-1 (IGF-1) were tested in an experimental model of cardiac failure treated with chronic angiotensin-converting enzyme (ACE) inhibition. Myocardial infarction was induced in rats by left coronary artery ligation. Two weeks after ligation, the animals received either captopril (2 g/L in drinking water) or water for 3 months. The rats were then given either GH (2 mg/kg/day) plus IGF-1 (2 mg/kg/day) or vehicle for 14 days. Captopril treatment decreased mean arterial pressure (MAP), left ventricular end-diastolic pressure (LVEDP) and systemic vascular resistance (SVR) (p < 0.05), and increased cardiac index (CI) and stroke volume index (SVI) (p < 0.05). GH/IGF-1 or captopril+GH/IGF-1 treatment decreased MAP, LVEDP, and SVR (p < 0.05), and increased left ventricular maximum dP/dt, CI, and SVI (p < 0.05). The increases in CI and SVI were significantly greater in the captopril+GH/IGF-1-treated animals than in those treated with captopril alone (p < 0.05). The beneficial effect of captopril in reducing cardiac hypertrophy was preserved in the captopril+GH/IGF-1 group. The results indicate that GH/IGF-1 and captopril can improve cardiac performance in congestive heart failure by independent and complementary mechanisms.
Authors:
H Jin; R Yang; N Gillett; R G Clark; A Ko; N F Paoni
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  26     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  420-5     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Research, Genentech, Inc., South San Francisco, California 94080, USA.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  pharmacology,  therapeutic use*
Animals
Blood Pressure / drug effects
Body Weight / drug effects
Captopril / administration & dosage,  pharmacology,  therapeutic use*
Cardiac Output / drug effects
Disease Models, Animal
Drug Synergism
Drug Therapy, Combination
Growth Hormone / administration & dosage,  blood,  pharmacology,  therapeutic use*
Heart Failure / drug therapy*
Heart Rate / drug effects
Hypertrophy, Left Ventricular / drug therapy
Insulin-Like Growth Factor I / administration & dosage,  metabolism,  pharmacology,  therapeutic use*
Male
Myocardial Infarction / drug therapy
Rats
Rats, Sprague-Dawley
Stroke Volume / drug effects
Vascular Resistance / drug effects
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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