Document Detail


Beneficial effects of gradual intense exercise in tissues of rats fed with a diet deficient in vitamins and minerals: a pilot study.
MedLine Citation:
PMID:  19131214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study evaluated the preliminary effects of intense physical training (swimming) on oxidative stress in rats with nutritional deficiencies. METHODS: Rats were fed with a standard diet or a diet deficient in vitamins and minerals for 4 months. The deficient diet contained one-fourth of the recommended vitamin and mineral levels for rats. From the second month, half of the animals were subjected to a swimming exercise in a plastic container with water maintained at 34 +/- 1 degrees C for 1 h/d, five times per week, for 11 wk. The rats were subjected to swimming exercise with loads attached to the dorsal region, which were progressively increased according to their body weight (1% to 7%). Sedentary rats were transported to the experimental room and handled as often in a similar way as the exercise group, except that they were not put in water. RESULTS: In the exercised group, blood lactate levels were significantly lower and the heart weight/body weight ratio was significantly higher than in the sedentary group (P < 0.05). Increased lipid peroxidation was observed in the liver, heart, and skeletal muscle of rats fed with the deficient diet, but it was completely reversed by exercise. Exercise also decreased lipid peroxidation levels in the heart and skeletal muscle of rats fed with the standard diet (P < 0.05). CONCLUSION: This pilot study leads to the continuity of the studies, because the partial results observed suggest that inadequate nutrition may enhance oxidative stress, and that intense chronic physical training may activate antioxidant defenses, possibly by hormesis.
Authors:
Angélica Teixeira; Liz Müller; Alessandra A dos Santos; Patrícia Reckziegel; Tatiana Emanuelli; João Batista T Rocha; Marilise E Bürger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-08
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  25     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  590-6     Citation Subset:  IM    
Affiliation:
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Antioxidants / metabolism*
Avitaminosis / blood,  metabolism,  physiopathology*
Deficiency Diseases / blood,  metabolism,  physiopathology*
Heart / anatomy & histology*
Lactic Acid / blood
Lipid Peroxidation
Liver / anatomy & histology,  metabolism
Male
Minerals / administration & dosage
Muscle, Skeletal / anatomy & histology,  metabolism
Myocardium / metabolism
Organ Size
Oxidation-Reduction
Oxidative Stress*
Physical Conditioning, Animal / physiology*
Pilot Projects
Random Allocation
Rats
Rats, Wistar
Swimming
Thiobarbituric Acid Reactive Substances
Vitamins / administration & dosage
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Minerals; 0/Thiobarbituric Acid Reactive Substances; 0/Vitamins; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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