| Beneficial effects of extended-release doxazosin and doxazosin standard on sexual health. | |
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MedLine Citation:
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PMID: 16469026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of benign prostatic hypertrophy (BPH) and erectile dysfunction (ED) both increase with age, and increasing evidence suggests a common cause rather than independent age-related changes. Arterial hypertension often accompanies these urological disorders, suggesting the possibility that increased alpha-adrenoceptor activity may be causal in all three conditions. As evidence for this model, alpha-adrenoceptor antagonists such as doxazosin produce therapeutically beneficial effects in lowering blood pressure, reducing prostate growth and BPH symptoms, and relieving ED. At postjunctional alpha(1)-receptors in the corpus cavernosa, noradrenaline causes vascular smooth muscle cell contraction, restricting blood flow, resulting in penile detumescence. Just as alpha-adrenoceptor antagonism results in systemic vasorelaxation to lower blood pressure, the same mechanism in the penis modulates the effects of noradrenaline to favour vasodilatation, resulting in improved erectile function. Increasing clinical evidence attests to the effectiveness of doxazosin in relieving ED, even in patients refractory to ED-specific treatment, as well as in reducing BPH symptoms and elevated blood pressure. |
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Authors:
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Steven A Kaplan; Aldo F DE Rose; Roger S Kirby; Michael P O'leary; Kevin T McVary |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: BJU international Volume: 97 ISSN: 1464-4096 ISO Abbreviation: BJU Int. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-10 Completed Date: 2006-04-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100886721 Medline TA: BJU Int Country: England |
Other Details:
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Languages: eng Pagination: 559-66 Citation Subset: IM |
Affiliation:
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Columbia University, New York, NY, USA. kaplans@med.cornell.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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administration & dosage* Adult Aged Aged, 80 and over Delayed-Action Preparations / administration & dosage Doxazosin / administration & dosage* Erectile Dysfunction / drug therapy* Humans Hypertension / drug therapy* Libido / drug effects Male Middle Aged Patient Satisfaction Prostatic Hyperplasia / drug therapy* Quality of Life Treatment Outcome Vasodilation / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Delayed-Action Preparations; 74191-85-8/Doxazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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