Document Detail

Beneficial effects of exercising at moderate altitude on red cell oxygen transport and on exercise performance.
MedLine Citation:
PMID:  3714457     Owner:  NLM     Status:  MEDLINE    
The effect of a ascent to moderate altitude (2,300 m) and altitude training on the O2-transport properties of Hb and their possible consequences on tissue oxygenation during exercise were studied on six control and six training subjects. A rapid increase in P-50 values (+2.4 mm Hg, 0.32 kPa) was measured within one day after ascent. At the end of the stay at altitude (13th day) P-50 values were higher in subjects performing training than in controls. At altitude a slow but constant increase in 2,3-DPG, pyruvate kinase activity and reticulocyte count was found, which was more pronounced in training subjects as compared to controls. Ascent to altitude resulted in a decreased maximal performance capacity (-9%), but both groups recovered during the stay. In training subjects maximal exercise performance was increased after descent. Exercise at altitude was performed at a lower heart rate (controls: -10/min; training: -18/min) and at a lower lactate concentration (-4 mmol/l). These data indicate a positive effect of adaptation to altitude on exercise performance. Training itself shifts the ODC to the right and adds this effect to the effects of passive altitude adaptation on the O2-binding properties of hemoglobin.
H Mairbäurl; W Schobersberger; E Humpeler; W Hasibeder; W Fischer; E Raas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  406     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-24     Completed Date:  1986-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  594-9     Citation Subset:  IM; S    
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MeSH Terms
Biological Transport
Blood Chemical Analysis
Erythrocyte Count
Erythrocytes / metabolism*
Exercise Test
Heart Rate
Oxygen / blood*
Physical Endurance*
Physical Exertion*
Reg. No./Substance:

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