Document Detail

Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure.
MedLine Citation:
PMID:  17045979     Owner:  NLM     Status:  MEDLINE    
As endurance training improves symptoms and quality of life and decreases mortality rate and hospitalization, it is increasingly recognized as a beneficial practice for heart failure (HF) patients. However, the mechanisms involved in the beneficial effects of exercise training are far from being understood and need further evaluation. Independent of hemodynamics effects, exercise training participates in tissue remodeling. While heart failure induces a generalized metabolic myopathy, adaptation to endurance training mainly improves energetic aspects of muscle function. In the present review, after presenting the main characteristics of cardiac and skeletal muscle energy metabolism and the effects of exercise training, we will discuss the evidence for the beneficial effects of endurance training on cardiac and skeletal muscle oxidative metabolism and intracellular energy transfer in HF. These beneficial effects of exercise training seen in heart failure patients are also relevant to other chronic diseases (chronic obstructive pulmonary disease, diabetes, and obesity) and even for highly sedentary or elderly individuals [Booth F.W., Chakravathy M.V., Spangenburg E.E. Exercise and gene expression: physiological regulation of the human genome through physical activity. J Physiol (Lond) 2002;543:399-411]. Physical rehabilitation is thus a major health issue for populations in industrialized countries.
Renée Ventura-Clapier; Bertrand Mettauer; Xavier Bigard
Related Documents :
922079 - Instrumental conditioning of human heart rate during free and controlled respiration.
8063649 - Adaptation and overtraining in horses subjected to increasing training loads.
17123319 - The repeatability of submaximal endurance exercise testing in cystic fibrosis.
19528889 - Effects of aerobic exercise training on brain structure and psychological well-being in...
16388439 - Genome-wide scan to identify quantitative trait loci for baseline resting heart rate an...
1592059 - Biological responses to overload training in endurance sports.
22414319 - The effectiveness of a preferred intensity exercise programme on the mental health outc...
20732799 - Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese pos...
21178369 - Overtraining and elite young athletes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-09-16
Journal Detail:
Title:  Cardiovascular research     Volume:  73     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-04-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  10-8     Citation Subset:  IM    
INSERM U-769, Université Paris-Sud, 5 rue J-B Clément, F-92296, Châtenay-Malabry, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Energy Metabolism
Exercise Therapy / methods*
Heart Failure / metabolism*,  therapy*
Muscle, Skeletal / metabolism*
Myocardium / metabolism*
Physical Endurance*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Parallel Architecture perspective on language processing.
Next Document:  Development of a novel fragments absorbed immunocapture enzyme assay system for tartrate-resistant a...