Document Detail


Beneficial effects of defibrotide against myocardial ischemia and decline of beta-adrenoceptor function in the rabbit.
MedLine Citation:
PMID:  3011616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Defibrotide is a polydeoxyribonucleotide of mammalian origin which possesses profibrinolytic effect and PGI2-releasing capacity. Because of these properties, defibrotide has antithrombotic effects which are demonstrated in various experimental models of venous and arterial thrombosis. The present study indicates that defibrotide clearly protects against myocardial damage in the rabbit 3 days after total coronary artery occlusion. Furthermore, defibrotide prevents the decline of beta-adrenergic receptor function, a phenomenon related to excessive circulating catecholamines that occurs during the myocardial infarct. Defibrotide prevents the dramatic fall of creatine phosphokinase activity in the ischemic ventricle: metabolic changes which reflect changes in the cells affected by prolonged ischemia. Assumptions about the mode of action of defibrotide are given particularly in consideration of the interaction between the fibrinolytic activity and the PGI2-releasing capacity of this substance.
Authors:
F Berti; G Rossoni; R Niada; C Omini; M Pretolani; C Mandelli
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Haemostasis     Volume:  16 Suppl 1     ISSN:  0301-0147     ISO Abbreviation:  Haemostasis     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0371574     Medline TA:  Haemostasis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Creatine Kinase / metabolism
Fibrinolytic Agents / pharmacology*
Histamine / pharmacology
Isoproterenol / antagonists & inhibitors
Ligation
Male
Myocardial Contraction / drug effects*
Myocardial Infarction / drug therapy*
Myocardium / enzymology
Polydeoxyribonucleotides / pharmacology*
Pressure
Rabbits
Receptors, Adrenergic, beta / drug effects*
Receptors, Histamine / drug effects
Tyramine / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Polydeoxyribonucleotides; 0/Receptors, Adrenergic, beta; 0/Receptors, Histamine; 438HCF2X0M/defibrotide; 51-45-6/Histamine; 51-67-2/Tyramine; 7683-59-2/Isoproterenol; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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