| Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats. | |
MedLine Citation:
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PMID: 19387578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A combination of antihypertensive agents can better control blood pressure and reduce the number and severity of side effects than a monotherapy. Since both CCBs (calcium channel blockers) and ARBs (angiotensin II receptor type-1 blockers) are current and effective antihypertensive drugs, this study assessed the synergistic antihypertensive effects as well as the optimal combination ratio of these two drugs. Amlodipine (3 mg/kg) or losartan (30 mg/kg) alone or a combination of each drug at a ratio 1:10 and 1:20 was administered orally to spontaneously hypertensive rats (SHR). A four-week treatment of either 3 mg/kg amlodipine or 30 mg/kg losartan alone decreased the systolic blood pressure (SBP). However, their combination significantly lowered the SBP from the 3(rd) week, and there was a positive correlation between this reduction in blood pressure and the improvement in arterial endothelium-dependent relaxation. In addition, the combination therapy (1:20) decreased both the cardiac mass and left ventricular weight to a greater extent than with either amlodipine or losartan alone. The collagen content in the cardiac tissue was also significantly lower after the 4-week combination therapy (1:10). These results suggest that the combined use of amlodipine and losartan might be more effective in treating hypertension than a monotherapy. |
Authors:
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Seul Min Choi; Mi Jeong Seo; Kyung Koo Kang; Jeong Hoon Kim; Byoung Ok Ahn; Moohi Yoo |
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Publication Detail:
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Type: Journal Article Date: 2009-04-23 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 32 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-04-23 Completed Date: 2009-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 353-8 Citation Subset: IM |
Affiliation:
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Research Center, Dong-A Pharmaceutical Company, Yongin, 446-905, Korea. csm@donga.co.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
/
pharmacology Administration, Oral Amlodipine / administration & dosage, pharmacology* Angiotensin II Type 1 Receptor Blockers / administration & dosage, pharmacology* Animals Antihypertensive Agents / administration & dosage, pharmacology* Aorta / drug effects, physiopathology Blood Pressure / drug effects* Body Weight / drug effects Calcium Channel Blockers / administration & dosage, pharmacology* Cardiomegaly / etiology, prevention & control Collagen / metabolism Disease Models, Animal Drug Therapy, Combination Hypertension / complications, drug therapy*, physiopathology Losartan / administration & dosage, pharmacology* Myocardium / metabolism Rats Rats, Inbred SHR Time Factors Vasodilation / drug effects Vasodilator Agents / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Vasodilator Agents; 114798-26-4/Losartan; 51-84-3/Acetylcholine; 88150-42-9/Amlodipine; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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