Document Detail

Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients.
MedLine Citation:
PMID:  17906875     Owner:  NLM     Status:  MEDLINE    
Recent studies showed that tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), as well as high-sensitive C-reactive protein (hsCRP) levels are predictive factors of cardiovascular risk. However, the effect of cardiac rehabilitation (CR) intervention in coronary artery disease (CAD) patients on these factors is not known. The aim of this study was to evaluate the effects of CR and exercise on hsCRP and inflammatory cytokine levels in patients with CAD after percutaneous coronary intervention (PCI). CAD patients who underwent PCI were divided into a CR and exercise group (CRE, n = 29) or a control group (CON, n = 10). CR and exercise consisted of 6 weeks supervised exercise training and 8 weeks home-based, self-managed exercise. Compared to pre-experimental levels, TNF-alpha (by 20.4%; p = 0.006) and IL-6 (by 49.0%; p < 0.0001), as well as hsCRP (by 59.4%; p < 0.0001), were markedly decreased after CR and exercise in CAD patients but not in control group, except for IL-6 (by 41.6%; p = 0.001). However, there was no significant alteration of adiposity-related variables such as BMI, percent body fat, and waist circumferences, in both groups. We suggest that CR and exercise in CAD patients after PCI induce significant reduction in hsCRP and inflammatory cytokines (TNF-alpha and IL-6), and marked increase in exercise tolerance and capacity.
Young-Joo Kim; Young-Oh Shin; Jun-Sang Bae; Jeong-Beom Lee; Joo-Hyun Ham; Youn-Jung Son; Jung-Kyu Kim; Chul Kim; Byoung-Kwon Lee; Jae-Keun Oh; Timothy Othman; Young-Ki Min; Hun-Mo Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-29
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  455     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1081-8     Citation Subset:  IM    
Department of Rehabilitation Medicine, College of Medicine, Inje University, Seoul, Republic of Korea.
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MeSH Terms
Adiposity / physiology
Angioplasty, Transluminal, Percutaneous Coronary
Blood Cell Count
Blood Chemical Analysis
Blood Pressure / physiology
C-Reactive Protein / metabolism*
Coronary Artery Disease / physiopathology*,  rehabilitation*
Cytokines / metabolism*
Exercise Test
Exercise Therapy*
Exercise Tolerance / physiology
Fibrinogen / metabolism
Heart Function Tests
Leukocyte Count
Lipids / blood
Middle Aged
Oxygen Consumption
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Cytokines; 0/Lipids; 0/Tumor Necrosis Factor-alpha; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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