| Beneficial effect of the traditional chinese drug shu-xue-tong on recovery of spinal cord injury in the rat. | |
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MedLine Citation:
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PMID: 20953395 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Shu-Xue-Tong (SXT) is a traditional Chinese drug widely used to ameliorate stagnation of blood flow, such as brain or myocardial infarction. Whether SXT may have therapeutic value for spinal cord injury (SCI), during which ischemia plays an important role in its pathology, remains to be elucidated. We hypothesized that SXT may promote SCI healing by improving spinal cord blood flow (SCBF), and a study was thus designed to explore this possibility. Twenty-five male Sprague-Dawley rats were used. SCI was induced by compression, and SXT was administrated 24 h postinjury for 14 successive days. The effects of SXT were assessed by means of laser-Doppler flowmetry, motor functional analysis (open-field walking and footprint analysis), and histological analysis (hematoxylin-eosin and thionin staining and NeuN immunohistochemistry). SXT significantly promoted SCBF of the contused spinal cord and enhanced the recovery of motor function. Histological analysis indicated that the lesion size was reduced, the pathological changes were ameliorated, and more neurons were preserved. Based on these results we conclude that SXT can effectively improve SCI. |
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Authors:
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Li-Yun Jia; An-Hui Yao; Fang Kuang; Yu-Kai Zhang; Xue-Feng Shen; Gong Ju |
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Publication Detail:
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Type: Journal Article Date: 2010-09-08 |
Journal Detail:
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Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2011 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2011 |
Date Detail:
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Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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Institute of Neurosciences, The Fourth Military Medical University, 17 Changlexi Road, Xi'an 710032, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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