Document Detail

Beneficial effect of splenic artery ligation on bacterial translocation after major liver resection in rats.
MedLine Citation:
PMID:  23157976     Owner:  NLM     Status:  Publisher    
OBJECTIVE: In major liver resection, bacterial translocation appears to be an important mechanism in the pathogenesis of spontaneous infection. This study was designed to investigate the effects of splenic artery ligation on bacterial translocation after major liver resection. MATERIALS AND METHODS: Rats were divided into three groups: the sham operation group (SO group), the two-thirds partial hepatectomy group (PHx group) and the two-thirds partial hepatectomy plus splenic artery ligation group (PHx+Sp group). Bacterial translocation, endotoxemia, d-lactic acid and intestinal histology were analyzed among three groups. RESULTS: The rate of bacterial translocation was higher in the PHx rats than in the SO rats (65.0% vs. 6.67%; P=0.001), so that in the PHx+Sp rats (25.0%; P=0.011). Endotoxemia was not evident in the SO rats (0pg/ml) and blood endotoxin levels decreased in the PHx+Sp rats (1.47pg/ml) compared with the PHx rats (4.05pg/ml, P<0.001). d-lactic acid was also higher in both the PHx and PHx+Sp rats compared with the SO rats (39.09mg/ml, 23.36mg/ml, and 1.68mg/ml; P<0.01). CONCLUSION: Splenic artery ligation enhanced intestinal barrier function and diminished blood endotoxin levels and bacterial translocation in rats with major liver resection.
Wen-Zhe Chen; Kun-Peng Hu; Rui-Yun Xu; Wei-Dong Pan
Related Documents :
6543626 - Tail pinch induced eating: psychogenetic comparison of roman high- and low-avoidance rats.
3212056 - Sex differences in passive avoidance behavior of rats: sex-dependent susceptibility to ...
22084716 - Hypolipidemic and antiobesity-like activity of standardised extract of hypericum perfor...
15837146 - Differential effects of periodic maternal separation on adult stress coping in a rat mo...
10100506 - Identification of non-acetylated metallothioneins induced in rat liver by zinc.
22366466 - The impact of hepatic denervation on the accumulation of hepatic progenitor cells durin...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  -     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Department of Hepatobiliary Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small-bowe...
Next Document:  Modeling the hepatic arterial buffer response in the liver.