Document Detail


Beneficial effect of sodium sucrose-sulfate on the ocular surface of patients with severe KCS in primary Sjögren's syndrome.
MedLine Citation:
PMID:  1750307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sucralfate (aluminium sucrose-sulfate), a well known gastric mucosal protectant, has been tested topically on 22 patients (20 females and 2 males) suffering from primary Sjögren's syndrome. Median treatment period was 6 months (range 1-19 months). Statistically significant improvement in the ocular surface condition was found judged from the reduction in Rose-Bengal score (P less than or equal to 0.00005). The beneficial effect appeared within the first 1-4 months of treatment. No adverse side effects were encountered.
Authors:
J U Prause
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  69     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-01-23     Completed Date:  1992-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
Affiliation:
Eye Pathology Institute, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Aged
Cornea / pathology
Female
Humans
Keratoconjunctivitis Sicca / complications,  drug therapy*
Male
Middle Aged
Rose Bengal / diagnostic use
Sjogren's Syndrome / complications,  drug therapy*
Sucralfate / therapeutic use*
Tears / metabolism
Chemical
Reg. No./Substance:
11121-48-5/Rose Bengal; 54182-58-0/Sucralfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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