Document Detail

Beneficial effect of a new prostacyclin derivative on the walking capacity in patients with peripheral arterial insufficiency.
MedLine Citation:
PMID:  2478050     Owner:  NLM     Status:  MEDLINE    
The efficacy, tolerance and safety of iloprost, a stable analogue of carbaprostacyclin, were evaluated in 7 patients with peripheral arterial insufficiency at stage II of Fontaine's classification. After washout, placebo was infused intravenously for seven days, then iloprost was given by a six-hour intravenous infusion of 1 ng/kg/min over the next seven days. At the end of each period, the initial (ICD) and the absolute (ACD) claudication distance were measured by treadmill. The ankle/arm systolic blood pressure ratio (WI) was also assessed, at rest and ten minutes after exercise. As compared with placebo, ICD increased from 98 +/- 60 to 137 +/- 91 meters (p less than 0.05) and ACD from 151 +/- 76 to 210 +/- 95 meters (p less than 0.05). Similarly, WI rose from 0.44 +/- 0.14 to 0.52 +/- 0.18 (p less than 0.05) at rest and from 0.40 +/- 0.13 to 0.48 +/- 0.20 (p less than 0.05) ten minutes after treadmill exercise. Owing to the spontaneous fluctuation in walking distance experienced by such patients, an increase in ACD greater than or equal to 50% was considered as clinically relevant. In 3 patients, who experienced such an improvement, iloprost continued to be infused at the same dosage as before, for an additional seven days. In the remaining 4 patients (nonresponders), the dose was increased to 2 ng/kg/min.(ABSTRACT TRUNCATED AT 250 WORDS)
G Brevetti; A Rossini; S Perna; A Policicchio; T Attisano; M Ciotola; S Quattrin; M Condorelli; M Chiariello
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  40     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-03     Completed Date:  1989-11-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  907-13     Citation Subset:  IM    
Department of Medicine, 2nd Medical School, University of Naples, Italy.
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MeSH Terms
Blood Pressure / drug effects
Epoprostenol / therapeutic use*
Heart Rate / drug effects
Infusions, Intravenous
Intermittent Claudication / drug therapy*
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use*
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost

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