Document Detail

Beneficial effect of a low-fat low-calorie diet on myocardial energy metabolism in patients with angina pectoris.
MedLine Citation:
PMID:  6146007     Owner:  NLM     Status:  MEDLINE    
8 patients with exertional angina pectoris were treated for 3 months with a low-fat, low-calorie diet. Serum cholesterol was reduced by 28% and body-weight by 7.9 kg on average. The effect of the dietary intervention was assessed by a heart metabolic study during pacing-induced tachycardia. After dietary treatment coronary sinus blood-flow and myocardial oxygen consumption were considerably reduced, but pacing time before angina developed increased. Other improvements were a reduction in lactate release during pacing, a reduction in citrate release during recovery, a reduction in alanine output during rest and recovery, and a lower uptake of glutamate. The results suggest a beneficial effect of low-fat, low-calorie dietary treatment on myocardial energy metabolism in patients with exertional angina pectoris.
L Thuesen; T T Nielsen; A Thomassen; J P Bagger; P Henningsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-20     Completed Date:  1984-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  AIM; IM    
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MeSH Terms
Alanine / metabolism
Angina Pectoris / diet therapy*,  metabolism,  physiopathology
Cardiac Pacing, Artificial
Citrates / metabolism
Citric Acid
Dietary Fats / administration & dosage*
Energy Intake*
Energy Metabolism
Glutamates / metabolism
Heart Rate
Lactates / metabolism
Middle Aged
Myocardium / metabolism*
Oxygen Consumption
Reg. No./Substance:
0/Citrates; 0/Dietary Fats; 0/Glutamates; 0/Lactates; 56-41-7/Alanine; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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