Document Detail


Beneficial effect of ethamsylate on the relative blood flow of the pancreas in acute canine necrotizing pancreatitis.
MedLine Citation:
PMID:  7135174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The beneficial effect of ethamsylate in maintaining the relative pancreatic blood flow in acute canine necrotizing pancreatitis has been demonstrated. This beneficial effect is a function of the action of the drug in tending to maintain pancreatic blood flow, thereby minimizing the significant decrease which normally occurs in this parameter in acute necrotizing pancreatitis. The exact mechanism of action of the drug is unclear. Concurrent measurements of oxygen consumption by the pancreas show an apparent beneficial trend in the ethamsylate-treated group, although this was not proved to be statistically significant.
Authors:
A D Wells; W G Schenk
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  155     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Benzenesulfonates / therapeutic use*
Cardiac Output
Dogs
Ethamsylate / therapeutic use*
Necrosis
Oxygen Consumption
Pancreas / blood supply*,  metabolism
Pancreatitis / drug therapy,  metabolism,  physiopathology*
Regional Blood Flow
Grant Support
ID/Acronym/Agency:
AM26186/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Benzenesulfonates; 2624-44-4/Ethamsylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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