Document Detail


Beneficial effect of dexamethasone in decreasing the lethality of acute T-2 toxicosis.
MedLine Citation:
PMID:  1810806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Steroidal and non-steroidal anti-inflammatory agents were evaluated for effectiveness for treatment of acute T-2 toxicosis in mice. 2. Non-steroidal agents, indomethacin, phenylbutazone, and acetylsalicylic acid, either were ineffective, or potentiated the lethality of T-2 toxin. 3. Of the anti-inflammatory steroids tested, dexamethasone was the most effective. 4. Dexamethasone was administered before, at the same time as, or after injection of T-2 toxin. 5. As the time between toxin exposure and treatment was increased, there was a corresponding increase in lethality. 6. In conclusion, steroidal, but not non-steroidal, anti-inflammatory agents were effective in decreasing T-2 toxin-induced lethality.
Authors:
R F Fricke; J Jorge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  22     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-03     Completed Date:  1992-06-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1087-91     Citation Subset:  IM    
Affiliation:
U.S. Army Medical Research, Institute of Infectious Diseases, Ft Detrick, Frederick, MD 21701-5011.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Body Weight / physiology
Dexamethasone / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Lethal Dose 50
Male
Mice
Mice, Inbred ICR
T-2 Toxin / antagonists & inhibitors*,  toxicity
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 21259-20-1/T-2 Toxin; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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