| Beneficial effect of corticosteroids in catecholamine-dependent septic burn patients. | |
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MedLine Citation:
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PMID: 17382191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies indicated the benefit of hydrocortisone in septic patients based on the significant reduction of catecholamines and improved outcome in common intensive care patients. The treatment of intensive care burn patients with corticosteroids was discussed with great caution due to the especially compromised immune status of severely burned patients. The purpose of this study was to investigate the influence of corticosteroids in burn patients during septic shock. In our burn unit, we started with the administration of cortisol in 2001. In this retrospective study, 10 severely burned patients received, > or = 24h after norepinephrine dependency, hydrocortisone infusions of 200 mg/24 h. The course of norepinephrine dose, hemodynamic measurements (Swan-Ganz-Catheter) and daily Sequential Organ Failure Assessment (SOFA-Score) were analyzed and compared to nine (catecholamine-dependent) burn patients without cortisol therapy. Statistical analysis by means of Fisher's Exact Test revealed beneficial effects (morbidity and mortality) of low dose cortisol therapy compared to control patients. However, the results of this study must be interpreted with caution because of its limited number of patients and its retrospective character. Further randomized prospective controlled studies are necessary to determine the efficacy and safety of cortisol therapy in burn patients. |
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Authors:
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P Ch Fuchs; A Bozkurt; D Johnen; R Smeets; A Groger; N Pallua |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 33 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-03-26 Completed Date: 2007-07-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: England |
Other Details:
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Languages: eng Pagination: 306-11 Citation Subset: IM |
Affiliation:
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Department of Plastic, Reconstructive, and Hand Surgery, Burn Center, University Hospital RWTH, Aachen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anti-Inflammatory Agents / administration & dosage* Burns / drug therapy*, metabolism Case-Control Studies Female Humans Hydrocortisone / administration & dosage* Infusions, Intravenous Lung Diseases / etiology Male Middle Aged Norepinephrine / therapeutic use* Retrospective Studies Shock, Septic / drug therapy*, etiology, metabolism Steroid 11-beta-Hydroxylase / antagonists & inhibitors Urinary Tract Infections / etiology Vasoconstrictor Agents / therapeutic use* Wound Infection / etiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Vasoconstrictor Agents; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; EC 1.14.15.4/Steroid 11-beta-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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