| Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia. | |
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MedLine Citation:
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PMID: 20495831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a child with familial hypocalciuric hypercalcemia (FHH) in whom the hypercalcemia seemed to interfere with tissue healing after tympanoplasty. Consequently, he was placed on cinacalcet (30 mg/day), changed after 2 weeks to 60 mg/day. The treatment resulted in a decrease in serum parathyroid hormone (PTH) from 148 to 32 pg/mL (normal 7-75) and ionized calcium from 1.48 to 1.23 mmol/L (1.13-1.34), as well as successful healing of the revised surgical scar. Over the 12-month treatment period no complications were noted. We conclude that cinacalcet may be considered a new, and currently the only, tool in treating children with symptomatic FHH. |
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Authors:
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Uri S Alon; René G VandeVoorde |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-22 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 25 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1747-50 Citation Subset: IM |
Affiliation:
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Section of Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children's Mercy Hospitals and Clinics, University of Missouri at Kansas City, 2401 Gillham Road, Kansas City, MI 64108, USA. ualon@cmh.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood,
urine Calcium* / blood, urine Child Genetic Predisposition to Disease Humans Hypercalcemia / blood, drug therapy*, genetics, urine Male Mutation Naphthalenes / therapeutic use* Parathyroid Hormone / blood Pedigree Receptors, Calcium-Sensing / genetics Time Factors Treatment Outcome Tympanoplasty Wound Healing / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CASR protein, human; 0/Naphthalenes; 0/PTH protein, human; 0/Parathyroid Hormone; 0/Receptors, Calcium-Sensing; 364782-34-3/cinacalcet; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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